Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.53 |
| ▸ | MPO | P05164 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | CTSC | P53634 | 5/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.41 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL29062048 | 0.89 | OPRM1 (0.47) | KDM4EMAPTTSHRKMT2AMEN1 | |
| Tryptophan SCHEMBL530950 | 0.89 | KDM4E (0.68) | KDM4EMAPTTSHRKMT2AMEN1 | |
| Dl-Tryptophan SCHEMBL28798150 | 0.89 | KDM4E (0.68) | KDM4EMAPTTSHRKMT2AMEN1 | |
| Dl-Tryptophan SCHEMBL27136864 | 0.89 | KDM4E (0.68) | KDM4EMAPTTSHRKMT2AMEN1 | |
| Dl-Tryptophan SCHEMBL1533586 | 0.89 | KDM4E (0.68) | KDM4EMAPTTSHRKMT2AMEN1 | |
| Dl-Tryptophan SCHEMBL28512622 | 0.89 | KDM4E (0.68) | KDM4EMAPTTSHRKMT2AMEN1 | |
| Dl-Tryptophan SCHEMBL28518234 | 0.89 | KDM4E (0.68) | KDM4EMAPTTSHRKMT2AMEN1 | |
| Dl-Tryptophan SCHEMBL20164946 | 0.89 | KDM4E (0.68) | KDM4EMAPTTSHRKMT2AMEN1 | |
| Tryptophan SCHEMBL27622251 | 0.89 | KDM4E (0.68) | KDM4EMAPTTSHRKMT2AMEN1 | |
| Dl-Tryptophan SCHEMBL28880639 | 0.87 | KDM4E (0.45) | KDM4EMAPTTSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115814106-B | High-affinity inclusion peptide preparation and preparation method thereof | 东南大学 | 2024-03-22 | — | — | CN | disclosed |
| CN-115814106-A | High-affinity inclusion peptide preparation and preparation method thereof | 东南大学 | 2023-03-21 | — | — | CN | disclosed |