Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | KISS1R | Q969F8 | 11/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.43 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 2/20 | 0.43 |
| ▸ | NPY2R | P49146 | 2/20 | 0.43 |
| ▸ | NPY4R | P50391 | 2/20 | 0.43 |
| ▸ | IL1RN | P18510 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL29076836 | 0.89 | KMT2A (0.58) | OPRM1OPRD1KDM4EMEN1LMNA | |
| Tryptophan SCHEMBL29220361 | 0.89 | KISS1R (0.47) | KISS1RNPY2R | |
| Dl-Tryptophan SCHEMBL28985159 | 0.89 | KDM4E (0.53) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL27641203 | 0.89 | KMT2A (0.57) | OPRM1OPRD1KDM4EMEN1LMNA | |
| Dl-Tryptophan SCHEMBL28079150 | 0.89 | KMT2A (0.57) | OPRM1OPRD1KDM4EMEN1LMNA | |
| Dl-Tryptophan SCHEMBL29078368 | 0.88 | NPBWR1 (0.50) | OPRM1OPRD1KISS1RERAP2IL1RN | |
| Dl-Tryptophan SCHEMBL28131402 | 0.88 | KMT2A (0.58) | OPRM1OPRD1KDM4EMEN1LMNA | |
| Dl-Tryptophan SCHEMBL28861116 | 0.88 | KMT2A (0.58) | OPRM1OPRD1KDM4EMEN1LMNA | |
| Tryptophan SCHEMBL28979632 | 0.87 | KDM4E (0.45) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL28838628 | 0.87 | IL1RN (0.48) | OPRM1OPRD1KDM4EMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116672514-A | Preparation method of surface coating of plugging device and product thereof | 浙江大学 | 2023-09-01 | — | — | CN | disclosed |