Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Cyclohexylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL869134 | 0.96 | ALDH1A1 (0.40) | ALDH1A1MMP8MMP1MMP2SMYD3 | |
| Cyclohexylamine SCHEMBL643896 | 0.83 | SMYD3 (0.37) | ALDH1A1MMP8MMP1MMP2SMYD3 | |
| Cyclohexylamine SCHEMBL25275647 | 0.83 | APP (0.38) | EPHX1NAAAENPP2 | |
| Cyclohexylamine SCHEMBL31155310 | 0.82 | ALDH1A1 (0.40) | ALDH1A1MMP8MMP1MMP2SMYD3 | |
| SCHEMBL520280 | 0.81 | MMP8 (0.42) | ALDH1A1MMP8MMP1MMP2SMYD3 | |
| Cyclooctanamine SCHEMBL521739 | 0.81 | MMP8 (0.42) | ALDH1A1MMP8MMP1MMP2SMYD3 | |
| Cyclohexylamine SCHEMBL27416385 | 0.81 | MMP8 (0.42) | ALDH1A1MMP8MMP1MMP2SMYD3 | |
| Cyclohexylamine SCHEMBL3501943 | 0.81 | ALDH1A1 (0.41) | ALDH1A1MMP8MMP1CA1CA2 | |
| Cyclohexylamine SCHEMBL27744924 | 0.81 | ALDH1A1 (0.41) | ALDH1A1MMP8MMP1CA1CA2 | |
| Cyclohexylamine SCHEMBL28534696 | 0.80 | APP (0.39) | EPHX1NAAAENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111139229-B | Novel GDSL family lipid hydrolase EII-2 and encoding gene and application thereof | 自然资源部第二海洋研究所 | 2023-05-16 | — | — | CN | disclosed |
| CN-111019921-B | High-tolerance lipid hydrolase E93 and encoding gene and application thereof | 自然资源部第二海洋研究所 | 2023-04-28 | — | — | CN | disclosed |
| CN-111057691-B | Novel GDSL family lipid hydrolase EII-3 and encoding gene and application thereof | 自然资源部第二海洋研究所 | 2023-04-28 | — | — | CN | disclosed |