Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290238 | 0.83 | SMN1; SMN2 (0.56) | HPGDNPC1SMN1; SMN2GAAKDM4E | |
| SCHEMBL288852 | 0.83 | KDM4E (0.59) | HPGDNPC1SMN1; SMN2GAAKDM4E | |
| SCHEMBL2787018 | 0.81 | SMN1; SMN2 (0.41) | HPGDNPC1SMN1; SMN2GAAKDM4E | |
| SCHEMBL290307 | 0.81 | CD274 (0.61) | HPGDSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL298961 | 0.77 | NPC1 (0.62) | HPGDNPC1SMN1; SMN2GAAKDM4E | |
| SCHEMBL289671 | 0.77 | HTR2C (0.57) | NPC1SMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL289881 | 0.76 | SMN1; SMN2 (0.61) | HPGDNPC1SMN1; SMN2GAAKDM4E | |
| SCHEMBL289614 | 0.75 | KDM4E (0.64) | HPGDNPC1SMN1; SMN2GAAKDM4E | |
| SCHEMBL290239 | 0.75 | CYP2A6 (0.42) | — | |
| SCHEMBL3828069 | 0.74 | LMNA (0.51) | HPGDSMN1; SMN2GAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |