Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | MMP3 | P08254 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | KIF11 | P52732 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL200142 | 0.93 | LOXL2 (0.58) | LOXL2CYP2A6CYP19A1TSHRCA12 | |
| SCHEMBL9161636 | 0.86 | LOXL2 (0.54) | LOXL2CYP2A6CYP19A1HRH3CA12 | |
| SCHEMBL1641362 | 0.83 | HRH3 (0.61) | HRH3 | |
| Water SCHEMBL11480029 | 0.83 | HRH3 (0.45) | TSHRHRH3CA1CA2MAOB | |
| SCHEMBL14155434 | 0.81 | LOXL2 (0.58) | LOXL2CYP2A6MMP3CYP19A1TSHR | |
| SCHEMBL16848648 | 0.81 | LOXL2 (0.58) | LOXL2CYP2A6MMP3CYP19A1TSHR | |
| SCHEMBL2999573 | 0.81 | PARP15 (0.49) | LOXL2CYP2A6CYP19A1HRH3ALDH1A1 | |
| SCHEMBL9456876 | 0.80 | HRH3 (0.47) | TSHRHRH3CA1CA2MAOB | |
| SCHEMBL187751 | 0.80 | HRH3 (0.47) | TSHRHRH3CA1CA2MAOB | |
| SCHEMBL396846 | 0.80 | MMP3 (0.74) | LOXL2CYP2A6MMP3TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700653-B2 | Halogen-substituted aminodicarboxylic acid derivatives | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-04-20 | — | — | US | disclosed |
| US-7067694-B2 | Halogen-substituted amino dicarboxylic acid derivatives as medicaments for treating cardiovascular diseases | BAYER AKTIENGESELLSCHAFT (DE) | 2006-06-27 | — | — | US | disclosed |
| US-20060111444-A1 | Novel halogen-substituted aminodicarboxylic acid derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2006-05-25 | — | — | US | disclosed |
| EP-0574808-A1 | Amidine-biphenyl derivatives, process for their production & medical preparation containing them | Dr. Karl Thomae GmbH (DE) | 1993-12-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111444-A1 | Novel halogen-substituted aminodicarboxylic acid derivatives | FABP3, PPARD, FABP1 | LOXL2 334/4885CYP2A6 65/4885MMP3 1906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.