Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL4556412 | 0.81 | ALDH1A1 (0.35) | MEN1KMT2AKDM4ECYP3A4TDP1 | |
| Acetic Acid SCHEMBL15210198 | 0.75 | HDAC8 (0.41) | HSD17B10KDM4ESMN1; SMN2TSHRHDAC8 | |
| Hydrochloric Acid SCHEMBL2005070 | 0.73 | HDAC8 (0.48) | HSD17B10MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL587213 | 0.71 | HDAC8 (0.50) | HSD17B10MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL4413637 | 0.71 | GABRA1 (0.34) | MEN1KMT2AKDM4EALDH1A1HDAC8 | |
| Bromide SCHEMBL440497 | 0.69 | HDAC8 (0.48) | HSD17B10MEN1KMT2AKDM4ESMN1; SMN2 | |
| Acetic Acid SCHEMBL15210171 | 0.69 | NPC1 (0.35) | CYP1A2CYP2D6MAPK1MEN1KMT2A | |
| SCHEMBL751188 | 0.69 | SMN1; SMN2 (0.34) | CYP2D6HSD17B10SMN1; SMN2CYP2C19ALDH1A1 | |
| SCHEMBL4701353 | 0.68 | HDAC8 (0.31) | HDAC8 | |
| SCHEMBL362206 | 0.67 | HDAC8 (0.32) | HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116103358-A | Prostaglandin E synthesized by recombinant escherichia coli catalysis 2 Is a method of (2) | 合肥康诺生物制药有限公司 | 2023-05-12 | — | — | CN | disclosed |