SCHEMBL28999972

SCHEMBL28999972

O=[N+]([O-])/C=C/C1CC1(Cc1ccccc1)Cc1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FBP1 P09467 1/20 0.39
HTT P42858 4/20 0.36
MAPT P10636 3/20 0.36
NPSR1 Q6W5P4 3/20 0.36
ALDH1A1 P00352 2/20 0.36
HSP90AA1 P07900 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
MEN1 O00255 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
KMT2A Q03164 1/20 0.36
ATM Q13315 1/20 0.36
MAOA P21397 8/20 0.35
MAOB P27338 8/20 0.35
TLR4 O00206 3/20 0.35
TLR2 O60603 3/20 0.35
KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28999973 0.72 CTSL (0.41) ALDH1A1KMT2AMAOAMAOBTLR4
SCHEMBL30379032 0.70 FBP1 (0.36) FBP1HTTMAPTNPSR1ALDH1A1
SCHEMBL28999981 0.69
SCHEMBL28999988 0.69 FBP1 (0.38) FBP1MAPTNPSR1ALDH1A1HSP90AA1
SCHEMBL28999990 0.66 TLR4 (0.34) TLR4TLR2
SCHEMBL15093965 0.64 MAOB (0.56) FBP1HTTMAPTNPSR1ALDH1A1
SCHEMBL3890228 0.64 MAOB (0.56) FBP1HTTMAPTNPSR1ALDH1A1
SCHEMBL8627948 0.64 MAOB (0.56) FBP1HTTMAPTNPSR1ALDH1A1
SCHEMBL27847679 0.64 MAOA (0.36) HTTALDH1A1SMN1; SMN2MAOAMAOB
SCHEMBL28999992 0.63

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113121357-B 2-nitrovinyl cyclopropane compound and synthesis method thereof 上海大学 2023-05-16 CN disclosed