Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3150956 | 0.77 | HSD17B10 (0.40) | TDP1ALDH1A1HSD17B10TSHRALOX15 | |
| SCHEMBL1922270 | 0.72 | ALDH1A1 (0.50) | TDP1ALDH1A1HSD17B10TSHRALOX15 | |
| SCHEMBL449614 | 0.69 | TSHR (0.43) | TDP1ALDH1A1HSD17B10TSHRALOX15 | |
| SCHEMBL31387703 | 0.68 | APP (0.48) | CACNA2D1CACNB2CACNA1CALDH1A1ALOX15 | |
| SCHEMBL2798077 | 0.67 | ALDH1A1 (0.50) | CACNA2D1CACNB2CACNA1CTDP1ALDH1A1 | |
| SCHEMBL9524072 | 0.67 | TDP1 (0.39) | TDP1ALDH1A1HSD17B10TSHRALOX15 | |
| SCHEMBL3121931 | 0.65 | SMN1; SMN2 (0.39) | TDP1ALDH1A1HSD17B10TSHRALOX15 | |
| SCHEMBL3958189 | 0.65 | CACNA2D1 (0.43) | CACNA2D1CACNB2CACNA1C | |
| SCHEMBL4599196 | 0.65 | CACNA2D1 (0.56) | CACNA2D1CACNB2CACNA1CALDH1A1LMNA | |
| SCHEMBL983017 | 0.65 | GRM5 (0.45) | TDP1ALDH1A1HSD17B10ALOX15CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111471005-B | Indole-dihydronaphthalene compound and preparation method and application thereof | 南方科技大学 | 2023-04-07 | — | — | CN | disclosed |
| CN-111471005-A | Indole-dihydronaphthalene compound and preparation method and application thereof | 南方科技大学 | 2020-07-31 | — | — | CN | disclosed |