Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (2E)-Hexenoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 7/20 | 0.42 |
| ▸ | LPAR3 | Q9UBY5 | 5/20 | 0.42 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.42 |
| ▸ | LPAR4 | Q99677 | 3/20 | 0.42 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.42 |
| ▸ | LPAR6 | P43657 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | SELP | P16109 | 1/20 | 0.36 |
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (2E)-Hexenoic Acid SCHEMBL29010324 | 0.85 | P2RY10 (0.43) | SELP | |
| (2E)-Hexenoic Acid SCHEMBL29211309 | 0.80 | GABRR1 (0.43) | — | |
| Fumaric Acid SCHEMBL3889386 | 0.80 | PGK1 (0.50) | LPAR1LPAR3LPAR5ENPP2LPAR4 | |
| Monoethanolamine SCHEMBL5181889 | 0.80 | PGD (0.44) | LPAR1LPAR3LPAR5ENPP2LPAR4 | |
| Monoethanolamine SCHEMBL29242756 | 0.79 | PGD (0.43) | LPAR1LPAR3LPAR5ENPP2LPAR4 | |
| (2E)-Hexenoic Acid SCHEMBL28649890 | 0.78 | LPAR3 (0.46) | LPAR1LPAR3ENPP2LPAR2 | |
| (2E)-Hexenoic Acid SCHEMBL27903034 | 0.77 | GABRR1 (0.50) | ALDH1A1 | |
| Monoethanolamine SCHEMBL28333148 | 0.76 | LPAR5 (0.41) | LPAR1LPAR3LPAR5ENPP2LPAR4 | |
| Glycine SCHEMBL9225465 | 0.76 | PGK1 (0.46) | LPAR1LPAR3LPAR5ENPP2LPAR4 | |
| (2E)-Hexenoic Acid SCHEMBL29002245 | 0.76 | SMN1; SMN2 (0.48) | LPAR1S1PR1ALDH1A1TMEM97SELP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116133652-A | Method for preparing lipid nanoparticles | 摩登纳特斯有限公司 | 2023-05-16 | — | — | CN | claimed |
| CN-116133652-A | Method for preparing lipid nanoparticles | 摩登纳特斯有限公司 | 2023-05-16 | — | — | CN | disclosed |