Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30342159 | 0.86 | MAPT (0.48) | ABCB11CYP1A2CYP3A4TSHRHTR2A | |
| SCHEMBL30345151 | 0.84 | ABCB11 (0.48) | ABCB11CYP1A2CYP3A4TSHRHTR2A | |
| SCHEMBL11569483 | 0.72 | PPARA (0.71) | ABCB11CYP1A2CYP3A4TSHRHTR2A | |
| SCHEMBL29005152 | 0.70 | S1PR3 (0.43) | PPARACNR1MAPTALDH1A1GAA | |
| SCHEMBL29005216 | 0.69 | PRCP (0.49) | CNR1PRCP | |
| SCHEMBL29005173 | 0.68 | ALDH1A1 (0.54) | ABCB11CYP1A2CYP3A4TSHRHTR2A | |
| SCHEMBL14668158 | 0.67 | CYP3A4 (0.53) | ABCB11CYP1A2CYP3A4TSHRHTR2A | |
| SCHEMBL14668159 | 0.67 | CYP3A4 (0.53) | ABCB11CYP1A2CYP3A4TSHRHTR2A | |
| SCHEMBL2490473 | 0.66 | CYP3A4 (0.58) | ABCB11CYP1A2CYP3A4TSHRHTR2A | |
| SCHEMBL25220032 | 0.65 | ABCB11 (0.54) | ABCB11CYP1A2CYP3A4TSHRHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116134018-A | 2-oxoimidazolidine-4-carboxamide as NAV1.8 inhibitor | 默沙东有限责任公司 | 2023-05-16 | — | — | CN | disclosed |
| EP-4168393-A1 | 2-OXOIMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-04-26 | — | — | EP | disclosed |