Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | PTPRB | P23467 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29005139 | 0.86 | ABCB11 (0.45) | MAPTALDH1A1GAAPPARACYP1A2 | |
| SCHEMBL29005152 | 0.85 | S1PR3 (0.43) | MAPTALDH1A1GAAPPARAS1PR3 | |
| SCHEMBL30345151 | 0.79 | ABCB11 (0.48) | MAPTALDH1A1GAAPPARACYP1A2 | |
| SCHEMBL29005173 | 0.78 | ALDH1A1 (0.54) | MAPTALDH1A1GAAPPARACYP1A2 | |
| SCHEMBL2490507 | 0.75 | ABCB11 (0.49) | MAPTALDH1A1GAAPPARACYP1A2 | |
| SCHEMBL25227129 | 0.75 | PKM (0.46) | MAPTALDH1A1GAACYP1A2TSHR | |
| SCHEMBL25015984 | 0.72 | ALDH1A1 (0.54) | MAPTALDH1A1GAAPPARACYP1A2 | |
| SCHEMBL25787470 | 0.71 | PKM (0.46) | MAPTALDH1A1CYP1A2TSHRKDM4E | |
| SCHEMBL26179175 | 0.71 | PKM (0.42) | MAPTALDH1A1GAACYP1A2TSHR | |
| SCHEMBL11569483 | 0.71 | PPARA (0.71) | MAPTALDH1A1PPARACYP1A2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116134018-A | 2-oxoimidazolidine-4-carboxamide as NAV1.8 inhibitor | 默沙东有限责任公司 | 2023-05-16 | — | — | CN | disclosed |
| EP-4168393-A1 | 2-OXOIMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-04-26 | — | — | EP | disclosed |