Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.31 |
| ▸ | TYMS | P04818 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29010816 | 0.83 | MAPK10 (0.38) | GRM5GRM1NOS2MAPK10MAPK14 | |
| SCHEMBL29010834 | 0.76 | NOS2 (0.46) | NOS2MAPK10MAPK14HTR1AHTR7 | |
| SCHEMBL1009344 | 0.75 | CYP19A1 (0.41) | GRM5GRM1CYP19A1HTR1AHTR7 | |
| SCHEMBL28329716 | 0.69 | ACHE (0.39) | — | |
| SCHEMBL14246816 | 0.69 | GABRA5 (0.32) | MAPK10MAPK14 | |
| SCHEMBL3070384 | 0.69 | NISCH (0.38) | HTR1AHTR7CYP11B1CYP11B2 | |
| SCHEMBL29010811 | 0.68 | MAPK10 (0.37) | NOS2MAPK10MAPK14CYP19A1CYP11B2 | |
| SCHEMBL14246726 | 0.66 | ALDH1A1 (0.39) | MAPK10MAPK14MAOA | |
| SCHEMBL29010851 | 0.66 | MEN1 (0.42) | NOS2MAPK10MAPK14TYMS | |
| SCHEMBL6724928 | 0.65 | MAPK10 (0.45) | MAPK10MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116200357-B | Imine reductase mutant and application thereof in synthesis of chiral tetrahydroisoquinoline | 中国科学院天津工业生物技术研究所 | 2024-10-29 | — | — | CN | claimed |
| CN-116200357-A | Imine reductase mutant and application thereof in synthesis of chiral tetrahydroisoquinoline | 中国科学院天津工业生物技术研究所 | 2023-06-02 | — | — | CN | claimed |
| CN-116200357-B | Imine reductase mutant and application thereof in synthesis of chiral tetrahydroisoquinoline | 中国科学院天津工业生物技术研究所 | 2024-10-29 | — | — | CN | disclosed |
| CN-116200357-A | Imine reductase mutant and application thereof in synthesis of chiral tetrahydroisoquinoline | 中国科学院天津工业生物技术研究所 | 2023-06-02 | — | — | CN | disclosed |