Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 3/20 | 0.74 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | SRD5A1 | P18405 | 6/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.55 |
| ▸ | FNTA | P49354 | 3/20 | 0.55 |
| ▸ | FNTB | P49356 | 3/20 | 0.55 |
| ▸ | CDC25A | P30304 | 4/20 | 0.54 |
| ▸ | CDC25B | P30305 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | OSBP | P22059 | 1/20 | 0.51 |
| ▸ | RORC | P51449 | 1/20 | 0.51 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.51 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL863638 | 1.00 | USP2 (0.74) | USP2NPC1L1LMNASRD5A1SRD5A2 | |
| SCHEMBL14924215 | 1.00 | USP2 (0.74) | USP2NPC1L1LMNASRD5A1SRD5A2 | |
| SCHEMBL248175 | 0.90 | LMNA (0.63) | USP2NPC1L1LMNASRD5A1SRD5A2 | |
| SCHEMBL10584542 | 0.87 | LMNA (0.57) | USP2NPC1L1LMNASRD5A1SRD5A2 | |
| SCHEMBL26653759 | 0.87 | NPC1L1 (0.60) | USP2NPC1L1LMNAFNTAFNTB | |
| SCHEMBL10698627 | 0.86 | LMNA (0.55) | USP2NPC1L1LMNA | |
| SCHEMBL29289385 | 0.86 | GPBAR1 (0.69) | USP2NPC1L1LMNAFNTAFNTB | |
| SCHEMBL2482340 | 0.86 | USP2 (0.73) | USP2NPC1L1LMNASRD5A1SRD5A2 | |
| SCHEMBL2482342 | 0.86 | USP2 (0.73) | USP2NPC1L1LMNASRD5A1SRD5A2 | |
| SCHEMBL248173 | 0.85 | NPC1L1 (0.72) | USP2NPC1L1LMNASRD5A1SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116096429-A | Base editing of PCSK9 and methods of use thereof for treating diseases | 维乎医疗有限公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-116096883-A | Base editing of ANGPTL3 and methods of treating diseases using the same | 维乎医疗有限公司 | 2023-05-09 | — | — | CN | disclosed |