Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29850560 | 0.97 | POLB (0.36) | POLBKMT2AMEN1LMNATSHR | |
| SCHEMBL890976 | 0.83 | ALDH1A1 (0.40) | POLBKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL27595739 | 0.83 | LMNA (0.40) | POLBKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL18886520 | 0.82 | KMT2A (0.38) | POLBKMT2AMEN1LMNATSHR | |
| SCHEMBL31315862 | 0.82 | LMNA (0.39) | POLBKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL19435614 | 0.82 | KMT2A (0.38) | POLBKMT2AMEN1LMNATSHR | |
| Lithium Ion SCHEMBL22159591 | 0.81 | TAS1R3 (0.38) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28651722 | 0.81 | KMT2A (0.37) | POLBKMT2AMEN1LMNATSHR | |
| Lithium Ion SCHEMBL22470763 | 0.80 | HPGD (0.41) | KMT2AMEN1LMNAALDH1A1HPGD | |
| SCHEMBL29029117 | 0.79 | LMNA (0.38) | POLBKMT2AMEN1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116285386-A | Cartilage tissue repair hydrogel and preparation method thereof | 东南大学 | 2023-06-23 | — | — | CN | claimed |
| CN-118986854-A | Hydrogel and preparation method and application thereof | 华中科技大学 | 2024-11-22 | — | — | CN | disclosed |
| CN-116285386-A | Cartilage tissue repair hydrogel and preparation method thereof | 东南大学 | 2023-06-23 | — | — | CN | disclosed |