Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30126023 | 0.90 | PDE4B (0.44) | RETGPR119PDE4BMAPTJAK3 | |
| SCHEMBL30127474 | 0.90 | PDE4B (0.44) | RETGPR119PDE4BMAPTJAK3 | |
| SCHEMBL30126772 | 0.90 | PDE4B (0.44) | RETGPR119PDE4BMAPTJAK3 | |
| SCHEMBL29025845 | 0.86 | QDPR (0.38) | RET | |
| SCHEMBL22076873 | 0.83 | BTK (0.40) | RETJAK3BTK | |
| SCHEMBL25353312 | 0.82 | ALDH1A1 (0.45) | RETGPR119NAMPTMAPT | |
| SCHEMBL30576110 | 0.82 | ALDH1A1 (0.45) | RETGPR119NAMPTMAPT | |
| SCHEMBL30126320 | 0.82 | ALDH1A1 (0.45) | RETGPR119NAMPTMAPT | |
| SCHEMBL30576111 | 0.82 | ALDH1A1 (0.45) | RETGPR119NAMPTMAPT | |
| SCHEMBL30140211 | 0.81 | GPR119 (0.49) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109422755-B | Nitrogen-containing heterocyclic compound, preparation method, intermediate, composition and application | 上海医药集团股份有限公司 | 2023-07-04 | — | — | CN | disclosed |
| CN-109422755-A | A kind of nitrogen-containing heterocycle compound, preparation method, intermediate, composition and application | 上海医药集团股份有限公司 | 2019-03-05 | — | — | CN | disclosed |