Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 3/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | GRB7 | Q14451 | 3/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29397532 | 0.85 | HTT (0.56) | HTTKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL22963743 | 0.85 | HTT (0.56) | HTTKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL22963779 | 0.80 | KDM4E (0.56) | HTTKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL29396283 | 0.80 | KDM4E (0.56) | HTTKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL30908290 | 0.79 | KDM4E (0.61) | HTTKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL30349840 | 0.78 | ALDH1A1 (0.64) | HTTKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL6304842 | 0.78 | KDM4E (0.70) | HTTKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL22963740 | 0.77 | HTT (0.59) | HTTKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL29396281 | 0.77 | HTT (0.59) | HTTKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL22963739 | 0.77 | HTT (0.65) | HTTKDM4EALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116348115-A | Combination of antibody-drug conjugate and PARP1 selective inhibitor | 阿斯利康(英国)有限公司 | 2023-06-27 | — | — | CN | disclosed |