Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 3/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | MMP7 | P09237 | 1/20 | 0.45 |
| ▸ | GRB7 | Q14451 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22963743 | 1.00 | HTT (0.56) | HTTALDH1A1LMNAKDM4EL3MBTL1 | |
| SCHEMBL29026141 | 0.85 | HTT (0.57) | HTTALDH1A1LMNAKDM4EL3MBTL1 | |
| SCHEMBL30908290 | 0.81 | KDM4E (0.61) | HTTALDH1A1LMNAKDM4EL3MBTL1 | |
| SCHEMBL29396281 | 0.79 | HTT (0.59) | HTTALDH1A1LMNAKDM4EL3MBTL1 | |
| SCHEMBL22963740 | 0.79 | HTT (0.59) | HTTALDH1A1LMNAKDM4EL3MBTL1 | |
| SCHEMBL4249669 | 0.79 | KDM4E (0.61) | HTTALDH1A1LMNAKDM4EL3MBTL1 | |
| SCHEMBL22912783 | 0.78 | KDM4E (0.57) | HTTALDH1A1LMNAKDM4EL3MBTL1 | |
| SCHEMBL6304842 | 0.77 | KDM4E (0.70) | HTTALDH1A1LMNAKDM4EL3MBTL1 | |
| SCHEMBL25317041 | 0.77 | LMNA (0.51) | HTTALDH1A1LMNAKDM4EL3MBTL1 | |
| SCHEMBL30493526 | 0.77 | LMNA (0.51) | HTTALDH1A1LMNAKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116348115-B | Combination of antibody-drug conjugate and PARP1 selective inhibitor | ASTRAZENECA UK LTD. (GB) | 2026-05-26 | — | — | CN | disclosed |
| CN-114144413-B | PARP1 inhibitors | 阿斯利康(瑞典)有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-116348115-A | Combination of antibody-drug conjugate and PARP1 selective inhibitor | 阿斯利康(英国)有限公司 | 2023-06-27 | — | — | CN | disclosed |
| EP-3999506-A1 | PARP1 INHIBITORS | Astrazeneca AB (SE) | 2022-05-25 | — | — | EP | disclosed |
| CN-114144413-A | PARP1 inhibitors | 阿斯利康(瑞典)有限公司 | 2022-03-04 | — | — | CN | disclosed |