Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912510 | 0.98 | LMNA (0.49) | LMNAHTTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL535804 | 0.95 | ALDH1A1 (0.49) | LMNAHTTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4120039 | 0.90 | ALDH1A1 (0.50) | LMNAHTTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL15503157 | 0.85 | ALDH1A1 (0.49) | LMNASMN1; SMN2ALDH1A1KDM4EALOX15 | |
| SCHEMBL1607377 | 0.83 | LMNA (0.51) | LMNASMN1; SMN2ALDH1A1KDM4EALOX15 | |
| SCHEMBL277446 | 0.80 | LMNA (0.50) | LMNASMN1; SMN2ALDH1A1KDM4EALOX15 | |
| SCHEMBL12109353 | 0.79 | ALDH1A1 (0.46) | LMNAHTTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL5880878 | 0.79 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1ALOX15NPC1RAB9A | |
| SCHEMBL9983120 | 0.79 | DAGLA (0.46) | LMNAALDH1A1MAPTKMT2AFAAH | |
| SCHEMBL3441413 | 0.77 | ALDH1A1 (0.52) | LMNAHTTSMN1; SMN2ALDH1A1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258321-B2 | Beta-lactone compounds | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2012-09-04 | — | — | US | disclosed |
| EP-2212305-A1 | BETA-LACTONE COMPOUNDS | Burnham Institute for Medical Research (US) | 2010-08-04 | — | — | EP | disclosed |
| US-20090124681-A1 | BETA-LACTONE COMPOUNDS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-05-14 | — | — | US | disclosed |
| WO-2009059046-A1 | BETA-LACTONE COMPOUNDS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-05-07 | — | — | WO | disclosed |
| US-6849730-B2 | Methods of making porphyrins and related compounds with Lewis acids | NORTH CAROLINA STATE UNIVERSITY (US) | 2005-02-01 | — | — | US | disclosed |
| US-20030096978-A1 | Methods of making porphyrins and related compounds with Lewis acids | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124681-A1 | BETA-LACTONE COMPOUNDS | LBR, CYP8B1, GLB1 | LMNA 469/4885HTT 1420/4885SMN1; SMN2 3959/4885 |
| US-20030096978-A1 | Methods of making porphyrins and related compounds with Lewis acids | DDT, LIG3, SHARPIN | LMNA 1420/4885HTT 786/4885SMN1; SMN2 4827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.