Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16452808 | 0.77 | PTK2 (0.43) | SMN1; SMN2NPC1RAB9AALDH1A1MALT1 | |
| SCHEMBL23927035 | 0.75 | HPGD (0.40) | SMN1; SMN2NPC1ALDH1A1MALT1HTT | |
| SCHEMBL30079569 | 0.75 | HPGD (0.40) | SMN1; SMN2NPC1ALDH1A1MALT1HTT | |
| SCHEMBL23458490 | 0.71 | KCNMA1 (0.52) | SMN1; SMN2NPC1RAB9AALDH1A1HTT | |
| SCHEMBL27809895 | 0.70 | LMNA (0.35) | SMN1; SMN2HCAR2 | |
| SCHEMBL23926998 | 0.70 | ALDH1A1 (0.49) | GPR35SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL30258095 | 0.70 | ALDH1A1 (0.49) | GPR35SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL23927012 | 0.70 | ATR (0.46) | — | |
| SCHEMBL30079663 | 0.70 | ATR (0.46) | — | |
| SCHEMBL25256071 | 0.68 | GPR35 (0.58) | GPR35SMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107787322-B | Tricyclic compounds and their use as phosphodiesterase inhibitors | 辉瑞大药厂 | 2023-07-07 | — | — | CN | disclosed |