SCHEMBL2903205

SCHEMBL2903205

Clc1ccc(Oc2cc[c]cn2)c(Cl)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 3/20 0.45
HPGD P15428 3/20 0.45
TTR P02766 3/20 0.45
SLC6A3 Q01959 2/20 0.45
LMNA P02545 2/20 0.45
NR1I2 O75469 1/20 0.45
PGR P06401 1/20 0.45
HSP90AA1 P07900 1/20 0.45
ADORA3 P0DMS8 1/20 0.45
MAPT P10636 1/20 0.45
HSPA5 P11021 1/20 0.45
CBR1 P16152 1/20 0.45
TBXA2R P21731 1/20 0.45
AGTR1 P30556 1/20 0.45
S1PR4 O95977 4/20 0.40
SLC6A4 P31645 2/20 0.39
GRM8 O00222 1/20 0.39
GRM7 Q14831 1/20 0.39
GRM4 Q14833 1/20 0.39
HTT P42858 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2901099 0.87 LMNA (0.41) LMNASLC6A4HTTALDH1A1GAA
SCHEMBL10392932 0.84 SLC6A2 (0.43) SLC6A2HPGDSLC6A3MAPTS1PR4
SCHEMBL2897675 0.82 SLC22A12 (0.41) HPGDMAPTALDH1A1TDP1
SCHEMBL2901162 0.81 SLC6A2 (0.32) SLC6A2SLC6A3LMNAMAPTS1PR4
SCHEMBL693585 0.80 KMT2A (0.49) SLC6A2HPGDSLC6A3LMNASLC6A4
SCHEMBL5884573 0.77 PTGDR2 (0.49) SLC6A2HPGDSLC6A3SLC6A4ALDH1A1
SCHEMBL2901814 0.76 L3MBTL1 (0.44) HPGDLMNAMAPTHTTALDH1A1
SCHEMBL2894981 0.75 KMT2A (0.36) LMNAMAPTHTTGAA
SCHEMBL693084 0.74 CYP1A2 (0.50) SLC6A2SLC6A3LMNASLC6A4HTT
SCHEMBL2751221 0.74 TTR (0.45) SLC6A2HPGDTTRSLC6A3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100305124-A1 Acylated Aminopyridine and Aminopyridazine Insecticides BAYER CROPSCIENCE AG (DE) 2010-12-02 US disclosed
EP-2236505-A1 Acylated aminopyridines and pyridazines as insecticides Bayer CropScience AG (DE) 2010-10-06 EP disclosed
US-4954497-A AGRICULTURE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1990-09-04 US disclosed
EP-0330939-A2 Acrylic acid morpholides, their production and use Takeda Chemical Industries, Ltd. (JP) 1989-09-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100305124-A1 Acylated Aminopyridine and Aminopyridazine Insecticides AAAS, DDT, QDPR SLC6A2 2113/4885HPGD 977/4885TTR 2996/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.