Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 5/20 | 0.44 |
| ▸ | VNN1 | O95497 | 3/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.40 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203362 | 0.80 | FLT1 (0.49) | FYNKCNN3 | |
| SCHEMBL2905633 | 0.80 | HDAC3 (0.46) | HDAC3HDAC1HDAC2HDAC6FYN | |
| SCHEMBL2903422 | 0.78 | MMP13 (0.43) | HDAC3HDAC1HDAC2HDAC6FYN | |
| SCHEMBL1203062 | 0.74 | FYN (0.60) | HDAC3HDAC1HDAC2HDAC6FYN | |
| SCHEMBL1202935 | 0.73 | P4HTM (0.47) | FYN | |
| SCHEMBL2898694 | 0.70 | NTRK1 (0.54) | FYNNTRK1 | |
| SCHEMBL2905868 | 0.69 | FYN (0.50) | FYNNTRK1 | |
| SCHEMBL1203106 | 0.69 | NTRK1 (0.49) | NTRK1PTK2 | |
| SCHEMBL2905622 | 0.68 | FYN (0.72) | FYNNTRK1 | |
| SCHEMBL2903393 | 0.67 | KDM4E (0.47) | FYNVNN1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217601-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009060197-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2009-05-14 | — | — | WO | disclosed |