⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2902898 | 0.82 | — | — | |
| SCHEMBL16830498 | 0.67 | ALDH1A1 (0.36) | — | |
| SCHEMBL14001974 | 0.56 | PAK4 (0.40) | — | |
| SCHEMBL12456245 | 0.52 | PAK4 (0.35) | — | |
| SCHEMBL17103627 | 0.52 | — | — | |
| SCHEMBL12231956 | 0.51 | — | — | |
| SCHEMBL827155 | 0.47 | GABRA1 (0.35) | — | |
| SCHEMBL12018424 | 0.45 | LMNA (0.32) | — | |
| SCHEMBL12225582 | 0.45 | GABRA1 (0.33) | — | |
| SCHEMBL11802553 | 0.41 | HRH4 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3089980-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2018-01-31 | — | — | EP | claimed |
| EP-3083624-B1 | TETRAHYDRO-TETRAZOLO[1,5-A]PYRAZINES AS ROR-GAMMA INHIBITORS | MERCK PATENT GMBH (DE) | 2017-12-20 | — | — | EP | claimed |
| US-9688684-B2 | Substituted tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors | MERCK PATENT GMBH (DE) | 2017-06-27 | — | — | US | claimed |
| US-9670208-B2 | Serine/threonine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2017-06-06 | — | — | US | claimed |
| US-20160311830-A1 | TETRAHYDRO-TETRAZOLO[1,5-A]PYRAZINES AS ROR-GAMMA INHIBITORS | MERCK PATENT GMBH (DE) | 2016-10-27 | — | — | US | claimed |
| EP-3083624-A1 | TETRAHYDRO-TETRAZOLO[1,5-A]PYRAZINES AS ROR-GAMMA INHIBITORS | Merck Patent GmbH (DE) | 2016-10-26 | — | — | EP | claimed |
| US-20160304519-A1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2016-10-20 | — | — | US | claimed |
| WO-2015090507-A1 | TETRAHYDRO-TETRAZOLO[1,5-A]PYRAZINES AS ROR-GAMMA INHIBITORS | MERCK PATENT GMBH (DE) | 2015-06-25 | — | — | WO | claimed |
| EP-3089980-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2018-01-31 | — | — | EP | disclosed |
| EP-3083624-B1 | TETRAHYDRO-TETRAZOLO[1,5-A]PYRAZINES AS ROR-GAMMA INHIBITORS | MERCK PATENT GMBH (DE) | 2017-12-20 | — | — | EP | disclosed |
| US-9688684-B2 | Substituted tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors | MERCK PATENT GMBH (DE) | 2017-06-27 | — | — | US | disclosed |
| US-9670208-B2 | Serine/threonine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2017-06-06 | — | — | US | disclosed |
| EP-3089980-A1 | SERINE/THREONINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2016-11-09 | — | — | EP | disclosed |
| US-20160311830-A1 | TETRAHYDRO-TETRAZOLO[1,5-A]PYRAZINES AS ROR-GAMMA INHIBITORS | MERCK PATENT GMBH (DE) | 2016-10-27 | — | — | US | disclosed |
| EP-3083624-A1 | TETRAHYDRO-TETRAZOLO[1,5-A]PYRAZINES AS ROR-GAMMA INHIBITORS | Merck Patent GmbH (DE) | 2016-10-26 | — | — | EP | disclosed |
| US-20160304519-A1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2016-10-20 | — | — | US | disclosed |
| WO-2015103137-A1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2015-07-09 | — | — | WO | disclosed |
| WO-2015090507-A1 | TETRAHYDRO-TETRAZOLO[1,5-A]PYRAZINES AS ROR-GAMMA INHIBITORS | MERCK PATENT GMBH (DE) | 2015-06-25 | — | — | WO | disclosed |
| US-20100305124-A1 | Acylated Aminopyridine and Aminopyridazine Insecticides | BAYER CROPSCIENCE AG (DE) | 2010-12-02 | — | — | US | disclosed |
| EP-2236505-A1 | Acylated aminopyridines and pyridazines as insecticides | Bayer CropScience AG (DE) | 2010-10-06 | — | — | EP | disclosed |