Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 11/20 | 0.43 |
| ▸ | PGR | P06401 | 9/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 9/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29650348 | 0.78 | NR3C1 (0.50) | NR3C1PGRNR3C2SMN1; SMN2MAPK1 | |
| SCHEMBL19585644 | 0.78 | NR3C1 (0.44) | NR3C1PGRNR3C2SMN1; SMN2MAPK1 | |
| SCHEMBL2851614 | 0.78 | NR3C1 (0.50) | NR3C1PGRNR3C2SMN1; SMN2MAPK1 | |
| SCHEMBL31174785 | 0.76 | NR3C1 (0.46) | NR3C1PGRNR3C2SMN1; SMN2MAPK1 | |
| SCHEMBL17111036 | 0.76 | HTR6 (0.55) | SMN1; SMN2MAPK1P2RX4LMNAPDE4A | |
| SCHEMBL29696630 | 0.76 | HTR6 (0.55) | SMN1; SMN2MAPK1P2RX4LMNAPDE4A | |
| SCHEMBL4886606 | 0.75 | MEN1 (0.49) | NR3C1PGRNR3C2PDE4BPDE4D | |
| SCHEMBL7207556 | 0.75 | NR3C1 (0.42) | NR3C1PGRNR3C2SMN1; SMN2MAPK1 | |
| SCHEMBL8653902 | 0.75 | PDE5A (0.47) | NR3C1PGRNR3C2ALDH1A1KDM4E | |
| SCHEMBL11635971 | 0.74 | KMT2A (0.62) | NR3C1PGRNR3C2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115232070-A | Quinolinone alkaloid derivative containing acylhydrazone group on 1-site nitrogen atom and preparation method and application thereof | 太原理工大学 | 2022-10-25 | — | — | CN | claimed |
| CN-115232070-B | Quinolinone alkaloid derivative containing acylhydrazone group on 1-position nitrogen atom, and preparation method and application thereof | 太原理工大学 | 2023-06-30 | — | — | CN | disclosed |
| CN-115232070-A | Quinolinone alkaloid derivative containing acylhydrazone group on 1-site nitrogen atom and preparation method and application thereof | 太原理工大学 | 2022-10-25 | — | — | CN | disclosed |