Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8853888 | 1.00 | KMT2A (0.55) | KMT2AMEN1ALDH1A1PTGS1PTGS2 | |
| SCHEMBL3578270 | 0.80 | SRC (0.46) | LMNACYP1A2CYP2D6MAPK1 | |
| SCHEMBL8627633 | 0.80 | SRC (0.46) | LMNACYP1A2CYP2D6MAPK1 | |
| SCHEMBL8508888 | 0.79 | ALDH1A1 (0.50) | KMT2AMEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL23515278 | 0.76 | ALDH1A1 (0.40) | KMT2AMEN1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL16192842 | 0.75 | MIF (0.36) | KMT2AALDH1A1LMNACYP2D6MAPK1 | |
| SCHEMBL988808 | 0.75 | HPGD (0.42) | KMT2AALDH1A1LMNACYP2D6 | |
| SCHEMBL14521257 | 0.75 | KMT2A (0.53) | KMT2AMEN1ALDH1A1PTGS1PTGS2 | |
| SCHEMBL3909040 | 0.74 | HPGD (0.37) | ALDH1A1LMNAMAPK1 | |
| SCHEMBL2984292 | 0.73 | KMT2A (0.51) | KMT2AMEN1ALDH1A1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115232130-A | APN and AKT double-target-point inhibitor and preparation method and application thereof | 山东大学 | 2022-10-25 | — | — | CN | claimed |
| CN-115232130-B | APN and AKT double-target inhibitor and preparation method and application thereof | 山东大学 | 2024-01-12 | — | — | CN | disclosed |
| CN-115232130-A | APN and AKT double-target-point inhibitor and preparation method and application thereof | 山东大学 | 2022-10-25 | — | — | CN | disclosed |