Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.54 |
| ▸ | PRKACA | P17612 | 3/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.54 |
| ▸ | CDK2 | P24941 | 3/20 | 0.54 |
| ▸ | GSK3A | P49840 | 3/20 | 0.54 |
| ▸ | GSK3B | P49841 | 3/20 | 0.54 |
| ▸ | PRKX | P51817 | 3/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.54 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.54 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.54 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.54 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.54 |
| ▸ | CDK1 | P06493 | 2/20 | 0.54 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.54 |
| ▸ | AKT1 | P31749 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2750176 | 0.86 | ROCK2 (0.52) | NR1H4ROCK2ROCK1MAPK1PRKG1 | |
| SCHEMBL21467201 | 0.81 | CYP17A1 (0.57) | NR1H4ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2750327 | 0.81 | NR1H4 (0.52) | NR1H4MAPK1MEN1KMT2ALMNA | |
| SCHEMBL2748995 | 0.81 | NR1H4 (0.52) | NR1H4MAPK1MEN1KMT2ALMNA | |
| SCHEMBL4547701 | 0.78 | NR1H4 (0.49) | NR1H4ROCK2ROCK1MAPK1ALDH1A1 | |
| SCHEMBL4547700 | 0.78 | NR1H4 (0.46) | NR1H4MAPK1AKT1ALDH1A1MEN1 | |
| SCHEMBL263827 | 0.78 | NR1H4 (0.48) | NR1H4ROCK2ROCK1PRKG1RPS6KB1 | |
| SCHEMBL264134 | 0.77 | NR1H4 (0.47) | NR1H4ROCK2ROCK1MAPK1MEN1 | |
| SCHEMBL1644338 | 0.75 | NR1H4 (0.48) | NR1H4ROCK2ROCK1ALDH1A1LMNA | |
| SCHEMBL1838548 | 0.75 | BRPF1 (0.55) | NR1H4ALDH1A1MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178558-B2 | Substituted pyridylmethyl bicycliccarboxyamide compounds | PFIZER INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-8178558-B2 | Substituted pyridylmethyl bicycliccarboxyamide compounds | PFIZER INC. (US) | 2012-05-15 | — | — | US | disclosed |
| EP-2069302-B1 | SUBSTITUTED PYRIDYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER (US) | 2010-08-25 | — | — | EP | disclosed |
| US-20090318497-A1 | SUBSTITUTED PYRIDYLMETHYL BICYCLICCARBOXYAMIDE COMPOUNDS | PFIZER, INC. | 2009-12-24 | — | — | US | disclosed |
| US-20090318497-A1 | SUBSTITUTED PYRIDYLMETHYL BICYCLICCARBOXYAMIDE COMPOUNDS | PFIZER, INC. | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318497-A1 | SUBSTITUTED PYRIDYLMETHYL BICYCLICCARBOXYAMIDE COMPOUNDS | CNR1, CNR2, HCAR3 | NR1H4 665/4885ROCK2 4029/4885ROCK1 2768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.