Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 14/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | ROS1 | P08922 | 2/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | BUB1 | O43683 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29520314 | 1.00 | FGFR3 (0.55) | FGFR3KCNH2FGFR1FGFR2FGFR4 | |
| SCHEMBL29037743 | 0.95 | FGFR3 (0.53) | FGFR3KCNH2FGFR1FGFR2FGFR4 | |
| SCHEMBL29520366 | 0.95 | FGFR3 (0.53) | FGFR3KCNH2FGFR1FGFR2FGFR4 | |
| SCHEMBL29037754 | 0.80 | EML4 (0.47) | FGFR3EGFREML4ALKFLT3 | |
| SCHEMBL29520519 | 0.80 | EML4 (0.47) | FGFR3EGFREML4ALKFLT3 | |
| SCHEMBL29061912 | 0.80 | INSR (0.49) | FGFR3EGFRALKACVR1 | |
| SCHEMBL26465073 | 0.79 | FGFR3 (0.52) | FGFR3KCNH2FGFR1FGFR2FGFR4 | |
| SCHEMBL29520312 | 0.79 | KDM4E (0.48) | FGFR3KCNH2EGFRCDK4 | |
| SCHEMBL29037795 | 0.79 | KDM4E (0.48) | FGFR3KCNH2EGFRCDK4 | |
| SCHEMBL10036431 | 0.78 | FGFR3 (0.51) | FGFR3KCNH2FGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |