Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 9/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.47 |
| ▸ | RET | P07949 | 10/20 | 0.46 |
| ▸ | ROS1 | P08922 | 10/20 | 0.46 |
| ▸ | FLT3 | P36888 | 10/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29520519 | 1.00 | EML4 (0.47) | EML4ALKRETROS1FLT3 | |
| SCHEMBL29037795 | 0.87 | KDM4E (0.48) | FGFR3EGFRALDH1A1 | |
| SCHEMBL29520312 | 0.87 | KDM4E (0.48) | FGFR3EGFRALDH1A1 | |
| SCHEMBL29037743 | 0.85 | FGFR3 (0.53) | EML4ALKRETROS1FLT3 | |
| SCHEMBL29520366 | 0.85 | FGFR3 (0.53) | EML4ALKRETROS1FLT3 | |
| SCHEMBL29037744 | 0.81 | ALDH1A1 (0.46) | HRH3ALDH1A1 | |
| SCHEMBL29037679 | 0.80 | FGFR3 (0.55) | EML4ALKRETROS1FLT3 | |
| SCHEMBL29520314 | 0.80 | FGFR3 (0.55) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24124031 | 0.79 | GAA (0.50) | ALDH1A1 | |
| SCHEMBL10157374 | 0.77 | ALDH1A1 (0.42) | EML4ALKRETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |