Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 8/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.76 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.58 |
| ▸ | INSR | P06213 | 3/20 | 0.49 |
| ▸ | SNCA | P37840 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL31063745 | 1.00 | MAPT (0.76) | MAPTALDH1A1KDM4ETDP1POLB | |
| SCHEMBL13652077 | 0.98 | MAPT (0.73) | MAPTALDH1A1KDM4ETDP1POLB | |
| Iodide SCHEMBL4015595 | 0.86 | MAPT (1.00) | MAPTALDH1A1KDM4ETDP1POLB | |
| SCHEMBL8032355 | 0.84 | MAPT (0.97) | MAPTALDH1A1KDM4ETDP1POLB | |
| SCHEMBL9199430 | 0.82 | MAPT (0.53) | MAPTALDH1A1KDM4ETDP1POLB | |
| SCHEMBL11516370 | 0.80 | MAPT (0.50) | MAPTALDH1A1KDM4ETDP1POLB | |
| SCHEMBL9031405 | 0.79 | INSR (0.49) | MAPTALDH1A1KDM4ETDP1POLB | |
| Iodide SCHEMBL6366382 | 0.79 | MAPT (1.00) | MAPTALDH1A1KDM4ETDP1POLB | |
| Iodide SCHEMBL31063723 | 0.78 | MAPT (0.61) | MAPTALDH1A1KDM4ETDP1POLB | |
| SCHEMBL8003049 | 0.77 | MAPT (0.97) | MAPTALDH1A1KDM4ETDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116234578-A | Alpha 2 adrenoreceptor antagonists | 国立大学法人京都大学 | 2023-06-06 | — | — | CN | disclosed |