Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 2/20 | 0.51 |
| ▸ | SNCA | P37840 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | INSR | P06213 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11515558 | 0.98 | MAPT (0.58) | MAPTKDM4ELMNAPOLBRAB9A | |
| Iodide SCHEMBL31063683 | 0.84 | MAPT (0.64) | MAPTKDM4ELMNAPOLBRAB9A | |
| SCHEMBL14434817 | 0.82 | MAPT (0.61) | MAPTKDM4ELMNAPOLBRAB9A | |
| Iodide SCHEMBL31063860 | 0.81 | MAPT (0.47) | MAPTKDM4ELMNAPOLBRAB9A | |
| SCHEMBL9031987 | 0.78 | APP (0.50) | MAPTKDM4ELMNAPOLBRAB9A | |
| SCHEMBL29685190 | 0.78 | APP (0.50) | MAPTKDM4ELMNAPOLBRAB9A | |
| SCHEMBL11516326 | 0.78 | MAPT (0.45) | MAPTKDM4ELMNAPOLBRAB9A | |
| Iodide SCHEMBL31063745 | 0.78 | MAPT (0.76) | MAPTKDM4ELMNAPOLBMEN1 | |
| Iodide SCHEMBL29039127 | 0.78 | MAPT (0.76) | MAPTKDM4ELMNAPOLBMEN1 | |
| Iodide SCHEMBL1318387 | 0.77 | MAPT (0.55) | MAPTKDM4EPOLBRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024200263-A1 | 2-STYRYLBENZOTHIAZOLE DERIVATIVES AS α-SYNUCLEIN BINDING COMPOUNDS | EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) | 2024-10-03 | — | — | WO | disclosed |
| EP-4438597-A1 | 2-STYRYLBENZOTHIAZOLE DERIVATIVES AS A-SYNUCLEIN BINDING COMPOUNDS | Eberhard Karls Universität Tübingen Medizinische Fakultät (DE) | 2024-10-02 | — | — | EP | disclosed |