Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 8/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 2/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28946656 | 0.82 | BBOX1 (0.48) | TSHRKMT2AMAPTBLMGALR3 | |
| Hydrochloric Acid SCHEMBL2988641 | 0.82 | MAPT (0.42) | TSHRHPGDMAPTBLMGALR3 | |
| SCHEMBL28946676 | 0.80 | BBOX1 (0.53) | TSHRKMT2AMAPTBLMGALR3 | |
| Hydrochloric Acid SCHEMBL28658476 | 0.79 | TSHR (0.41) | TSHRHPGDDNM1HSP90AA1RAD52 | |
| Hydrochloric Acid SCHEMBL29171399 | 0.79 | TSHR (0.41) | TSHRHPGDDNM1HSP90AA1RAD52 | |
| Hydrochloric Acid SCHEMBL10684441 | 0.79 | TSHR (0.41) | TSHRHPGDDNM1HSP90AA1RAD52 | |
| Hydrochloric Acid SCHEMBL7870981 | 0.79 | TSHR (0.41) | TSHRHPGDDNM1HSP90AA1RAD52 | |
| SCHEMBL7592554 | 0.78 | TSHR (0.42) | TSHRHPGDHTTDNM1KMT2A | |
| SCHEMBL13727578 | 0.78 | TSHR (0.42) | TSHRHPGDHTTDNM1KMT2A | |
| SCHEMBL19347553 | 0.78 | TSHR (0.42) | TSHRHPGDHTTDNM1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101516926-B | Curable compositions and biofilm-resistant coatings therefrom | 3M INNOVATIVE PROPERTIES CO | 2011-08-03 | — | — | CN | disclosed |
| EP-2069410-B1 | CURABLE COMPOSITIONS AND BIOFILM-RESISTANT COATINGS THEREFROM | 3M INNOVATIVE PROPERTIES CO (US) | 2010-08-25 | — | — | EP | disclosed |
| US-7585919-B2 | Polymer derived from monomers with long-chain aliphatic, poly(oxyalkylene) and substrate-reactive groups | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2009-09-08 | — | — | US | disclosed |
| CN-101516926-A | Curable compositions and biofilm-resistant coatings therefrom | 3M INNOVATIVE PROPERTIES CO (US) | 2009-08-26 | — | — | CN | disclosed |
| EP-2069410-A1 | CURABLE COMPOSITIONS AND BIOFILM-RESISTANT COATINGS THEREFROM | 3M Innovative Properties Company (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008039670-A1 | CURABLE COMPOSITIONS AND BIOFILM-RESISTANT COATINGS THEREFROM | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2008-04-03 | — | — | WO | disclosed |
| US-20080075960-A1 | CURABLE COMPOSITIONS AND BIOFILM-RESISTANT COATINGS THEREFROM | 3M INNOVATIVE PROPERTIES COMPANY | 2008-03-27 | — | — | US | disclosed |