SCHEMBL29044196

SCHEMBL29044196

Nc1ncnc2[nH]c(-c3ccc(Cl)cc3)nc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 1/20 0.47
SRC P12931 1/20 0.47
PI4KA P42356 2/20 0.45
PI4K2B Q8TCG2 2/20 0.45
PI4K2A Q9BTU6 2/20 0.45
PI4KB Q9UBF8 2/20 0.45
MAP4K4 O95819 1/20 0.45
LMNA P02545 2/20 0.44
TSHR P16473 1/20 0.44
GAA P10253 4/20 0.44
KDM4E B2RXH2 3/20 0.44
MEN1 O00255 3/20 0.44
ALDH1A1 P00352 3/20 0.44
MAPT P10636 3/20 0.44
HPGD P15428 3/20 0.44
KMT2A Q03164 3/20 0.44
HSD17B10 Q99714 3/20 0.44
NPC1 O15118 2/20 0.44
TP53 P04637 2/20 0.44
RAB9A P51151 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL783583 0.85 PARP1 (0.47) LMNAGAAKDM4EMEN1ALDH1A1
SCHEMBL9175737 0.83 PI4KA (0.64) PI4KAPI4K2BPI4K2API4KBKDM4E
SCHEMBL29459254 0.83 PI4KA (0.64) PI4KAPI4K2BPI4K2API4KBKDM4E
Hydrochloric Acid SCHEMBL8595784 0.81 MAP4K4 (0.54) PI4KAPI4K2BPI4K2API4KBMAP4K4
SCHEMBL15756441 0.80 MAP4K4 (0.48) PI4KAPI4K2BPI4K2API4KBMAP4K4
SCHEMBL15756556 0.80 PIK3CD (0.50) PI4KAPI4K2BPI4K2API4KBLMNA
SCHEMBL15756646 0.80 ALDH1A1 (0.43) PI4KAPI4K2BPI4K2API4KBMAP4K4
SCHEMBL5025531 0.78 PI4KA (0.40) PI4KAPI4K2BPI4K2API4KBMAP4K4
SCHEMBL9692152 0.75 CCNB2 (0.46) GAAKDM4EALDH1A1MAPTHPGD
SCHEMBL3116678 0.75 LMNA (0.68) ABL1SRCPI4KAPI4K2BPI4K2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112209930-B Itratheophylline derivative, and preparation method and application thereof 山东新华制药股份有限公司 2023-05-16 CN disclosed