Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 5/20 | 0.36 |
| ▸ | TNKS | O95271 | 4/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADK | P55263 | 2/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29044196 | 0.78 | ABL1 (0.47) | PI4KAPI4K2BPI4K2API4KBPARP1 | |
| SCHEMBL9175737 | 0.77 | PI4KA (0.64) | PI4KAPI4K2BPI4K2API4KBPRMT5 | |
| SCHEMBL29459254 | 0.77 | PI4KA (0.64) | PI4KAPI4K2BPI4K2API4KBPRMT5 | |
| SCHEMBL15756441 | 0.77 | MAP4K4 (0.48) | PI4KAPI4K2BPI4K2API4KBPARP1 | |
| SCHEMBL15756646 | 0.77 | ALDH1A1 (0.43) | PI4KAPI4K2BPI4K2API4KBPARP1 | |
| SCHEMBL15756556 | 0.77 | PIK3CD (0.50) | PI4KAPI4K2BPI4K2API4KBPARP1 | |
| SCHEMBL15756483 | 0.68 | PIK3CD (0.54) | PI4K2APARP1TNKSTNKS2PIK3CG | |
| Hydrochloric Acid SCHEMBL8595784 | 0.67 | MAP4K4 (0.54) | PI4KAPI4K2BPI4K2API4KBPARP1 | |
| SCHEMBL5025525 | 0.66 | ADK (0.33) | PARP1ADK | |
| SCHEMBL8653515 | 0.65 | PI4KA (0.42) | PI4KAPI4K2BPI4K2API4KBPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940843-A2 | UNSATURATED HETEROCYCLIC DERIVATIVES | ARIAD PHARMACEUTICALS, INC. (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007021937-A2 | UNSATURATED HETEROCYCLIC DERIVATIVES | ARIAD PHARMACEUTICALS, INC. (US) | 2007-02-22 | — | — | WO | disclosed |