SCHEMBL290446

SCHEMBL290446

CCCC/C=C/c1cccc(C(=O)O)c1

nearest known ligand 0.60

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TTR P02766 4/20 0.53
UNG P13051 1/20 0.51
FBP1 P09467 1/20 0.50
STS P08842 2/20 0.49
P4HB P07237 2/20 0.48
KMT2A Q03164 1/20 0.44
PDE5A O76074 1/20 0.44
BID P55957 3/20 0.43
BCL2L1 Q07817 3/20 0.43
MCL1 Q07820 3/20 0.43
BAK1 Q16611 3/20 0.43
ALDH1A1 P00352 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
TSHR P16473 1/20 0.43
CYP2C19 P33261 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL290447 1.00 TTR (0.53) TTRUNGFBP1STSP4HB
SCHEMBL2817107 1.00 TTR (0.53) TTRUNGFBP1STSP4HB
Acetic Acid SCHEMBL11384341 0.97 TTR (0.50) TTRUNGFBP1STSP4HB
SCHEMBL9506061 0.94 STS (0.51) TTRUNGFBP1STSP4HB
SCHEMBL9504789 0.94 STS (0.51) TTRUNGFBP1STSP4HB
SCHEMBL9504784 0.94 STS (0.51) TTRUNGFBP1STSP4HB
SCHEMBL6560953 0.88 PDE5A (0.42) TTRUNGFBP1STSPDE5A
SCHEMBL20810556 0.87 FAAH (0.46) STSKMT2APDE5AALDH1A1CYP1A2
SCHEMBL13064621 0.84 P4HB (0.53) P4HBKMT2AALDH1A1CYP1A2CYP3A4
SCHEMBL880074 0.84 TTR (0.58) TTRUNGFBP1STSP4HB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3689849-B1 PERFUME PRECURSOR TAKASAGO PERFUMERY CO LTD (JP) 2025-01-15 EP claimed
US-8968452-B2 Phase change inks containing crystalline trans-cinnamic diesters and amorphous isosorbide oligomers XEROX CORPORATION (US) 2015-03-03 US claimed
US-8841055-B2 Super low melt emulsion aggregation toners comprising a trans-cinnamic di-ester XEROX CORPORATION (US) 2014-09-23 US claimed
US-8778069-B2 Phase change inks containing oligomeric rosin esters XEROX CORPORATION (US) 2014-07-15 US claimed
US-20140137767-A1 Phase Change Inks Containing Oligomeric Rosin Esters XEROX CORPORATION (US) 2014-05-22 US claimed
US-20130266896-A1 SUPER LOW MELT EMULSION AGGREGATION TONERS COMPRISING A TRANS-CINNAMIC DI-ESTER XEROX CORPORATION (US) 2013-10-10 US claimed
US-20130131226-A1 Phase Change Inks Containing Crystalline Trans-Cinnamic Diesters and Polyterpene Resins XEROX CORPORATION (US) 2013-05-23 US claimed
US-20130032056-A1 Phase Change Inks Containing Crystalline Trans-Cinnamic Diesters and Amorphous Isosorbide Oligomers XEROX CORPORATION (US) 2013-02-07 US claimed
US-20210002202-A1 Substituted Aromatic Compounds and Pharmaceutical Uses Thereof PROMETIC BIOSCIENCES, INC. (CA) 2021-01-07 US disclosed
US-10815183-B2 Substituted aromatic compounds and pharmaceutical uses thereof PROMETIC PHARMA SMT LIMITED (GB) 2020-10-27 US disclosed
US-20180162799-A1 SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF PROMETIC PHARMA SMT LIMITED (GB) 2018-06-14 US disclosed
US-9938221-B2 Substituted aromatic compounds and pharmaceutical uses thereof PROMETIC PHARMA SMT LIMITED (GB) 2018-04-10 US disclosed
US-9487517-B2 Spiroimidazolone derivative CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2016-11-08 US disclosed
EP-2427416-B1 SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF PROMETIC PHARMA SMT LTD (GB) 2016-03-09 EP disclosed
EP-0021100-B1 CYCLOHEXENES ON THEIR OWN OR MIXED WITH (IV), PROCESS FOR PREPARATION OF (I), USE OF (I), OPTIONALLY (I+IV), AS AROMATIC AND/OR PERFUMERY SUBSTANCES, AND COMPOSITIONS OF AROMATIC AND/OR PERFUMERY SUBSTANCES THAT CONTAIN (I), OPTIONALLY (I+IV) L. GIVAUDAN & CIE Société Anonyme (CH) 1982-11-17 EP disclosed
EP-0045453-A1 Alkenols (I) and process for their preparation, utilisation of (I) as fragrants and/or aromatic compounds, as well as a fragrant and/or aromatic composition containing (I) L. GIVAUDAN & CIE Société Anonyme (CH) 1982-02-10 EP disclosed
EP-0011877-B1 CARANE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS PERFUMES, AND PERFUME COMPOSITIONS CONTAINING THEM L. Givaudan & Cie Société Anonyme (CH) 1981-05-20 EP disclosed
EP-0024306-A2 Substituted tetralines and indanes (I), use of (I) as perfuming and/or flavouring agents, and perfuming and/or flavouring compositions containing (I) L. Givaudan & Cie Société Anonyme (CH) 1981-03-04 EP disclosed
EP-0021100-A1 Cyclohexenes on their own or mixed with (IV), process for preparation of (I), use of (I), optionally (I+IV), as aromatic and/or perfumery substances, and compositions of aromatic and/or perfumery substances that contain (I), optionally (I+IV) L. GIVAUDAN & CIE Société Anonyme (CH) 1981-01-07 EP disclosed
EP-0011877-A1 Carane derivatives, process for their preparation, their use as perfumes, and perfume compositions containing them L. Givaudan & Cie Société Anonyme (CH) 1980-06-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180162799-A1 SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF TYR, PAH, REN TTR 220/4885UNG 2046/4885FBP1 1449/4885
US-10815183-B2 Substituted aromatic compounds and pharmaceutical uses thereof TYR, PAH, REN TTR 220/4885UNG 2046/4885FBP1 1449/4885
US-20210002202-A1 Substituted Aromatic Compounds and Pharmaceutical Uses Thereof TYR, PAH, REN TTR 220/4885UNG 2046/4885FBP1 1449/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.