Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 16/20 | 0.81 |
| ▸ | MMP13 | P45452 | 15/20 | 0.81 |
| ▸ | MMP3 | P08254 | 13/20 | 0.81 |
| ▸ | MMP1 | P03956 | 4/20 | 0.60 |
| ▸ | MMP9 | P14780 | 4/20 | 0.59 |
| ▸ | MMP8 | P22894 | 1/20 | 0.59 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2326046 | 0.89 | MMP13 (0.64) | MMP2MMP13MMP3MMP1MMP9 | |
| SCHEMBL4371861 | 0.89 | MMP2 (0.64) | MMP2MMP13MMP3MMP1MMP9 | |
| SCHEMBL8445758 | 0.83 | MMP2 (0.76) | MMP2MMP13MMP3MMP1MMP9 | |
| Tibeglisene SCHEMBL10419288 | 0.82 | MMP2 (0.55) | MMP2MMP13MMP3MMP1MMP9 | |
| SCHEMBL7892463 | 0.80 | MMP13 (1.00) | MMP2MMP13MMP3MMP1MMP9 | |
| SCHEMBL7456191 | 0.80 | MMP2 (0.81) | MMP2MMP13MMP3MMP1MMP9 | |
| SCHEMBL8650150 | 0.79 | TDP1 (0.77) | MMP2MMP13MMP3MMP1MMP9 | |
| SCHEMBL8387442 | 0.79 | TDP1 (0.77) | MMP2MMP13MMP3MMP1MMP9 | |
| SCHEMBL1260595 | 0.78 | MMP13 (0.51) | MMP2MMP13MMP3MMP1MMP9 | |
| SCHEMBL4342501 | 0.77 | MMP2 (0.59) | MMP2MMP13MMP3MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899298-B1 | DERIVATIVES OF 4,5-DIARYLPYRROLE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2010-08-18 | — | — | EP | disclosed |
| EP-1899298-A2 | DERIVATIVES OF 4,5-DIARYLPYRROLE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007000505-A2 | DERIVATIVES OF 4,5-DIARYLPYRROLE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2007-01-04 | — | — | WO | disclosed |