Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29985842 | 0.86 | KDM4E (0.68) | KDM4EALDH1A1HTR1ACYP1A2CYP2D6 | |
| SCHEMBL29985588 | 0.85 | KDM4E (0.67) | KDM4EALDH1A1HTR1ACYP1A2CYP2D6 | |
| SCHEMBL29045784 | 0.82 | ALDH1A1 (0.60) | KDM4EALDH1A1KMT2ASMN1; SMN2BACE1 | |
| SCHEMBL29045848 | 0.81 | ALDH1A1 (0.59) | KDM4EALDH1A1HTR1ACYP1A2CYP2D6 | |
| SCHEMBL29045812 | 0.80 | KDM4E (0.60) | KDM4EALDH1A1HTR1ACYP1A2CYP2D6 | |
| SCHEMBL29045814 | 0.72 | ALDH1A1 (0.56) | KDM4EALDH1A1KMT2ASMN1; SMN2FOXM1 | |
| SCHEMBL2474305 | 0.71 | ALDH1A1 (0.88) | KDM4EALDH1A1HTR1AKMT2AL3MBTL1 | |
| SCHEMBL29045835 | 0.71 | ALDH1A1 (0.55) | KDM4EALDH1A1HTR1AKMT2ASMN1; SMN2 | |
| SCHEMBL3862346 | 0.70 | PABPC1 (0.66) | KDM4EALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL12204698 | 0.70 | ALDH1A1 (0.65) | KDM4EALDH1A1HTR1AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304502-A | FOXM1 inhibitor and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2022-11-08 | — | — | CN | disclosed |