Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 7/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31352749 | 0.90 | KLKB1 (0.48) | KLKB1L3MBTL1ALDH1A1HSD17B10 | |
| SCHEMBL553848 | 0.86 | ALDH1A1 (0.60) | KLKB1L3MBTL1ALDH1A1TDP1CREBBP | |
| SCHEMBL17895755 | 0.86 | L3MBTL1 (0.60) | KLKB1L3MBTL1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL29117303 | 0.86 | GRM2 (0.61) | KLKB1ALDH1A1POLBCREBBPKDM4E | |
| SCHEMBL4785951 | 0.86 | HSD17B10 (0.59) | KLKB1L3MBTL1ALDH1A1POLBTDP1 | |
| SCHEMBL6426563 | 0.85 | KLKB1 (0.53) | KLKB1L3MBTL1ALDH1A1POLBTDP1 | |
| SCHEMBL31488288 | 0.84 | NPC1 (0.62) | KLKB1L3MBTL1ALDH1A1POLB | |
| SCHEMBL30730185 | 0.84 | POLB (0.62) | L3MBTL1ALDH1A1POLBTDP1KDM4E | |
| SCHEMBL28695464 | 0.83 | KDM4E (0.47) | L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL13692389 | 0.83 | L3MBTL1 (0.54) | KLKB1L3MBTL1ALDH1A1POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230286953-A1 | METHODS AND INTERMEDIATES FOR PREPARING JAK INHIBITORS | SUN PHARMACEUTICAL INDUSTRIES, INC. | 2023-09-14 | — | — | US | disclosed |
| US-20230286953-A1 | METHODS AND INTERMEDIATES FOR PREPARING JAK INHIBITORS | SUN PHARMACEUTICAL INDUSTRIES, INC. | 2023-09-14 | — | — | US | disclosed |
| US-20230286953-A1 | METHODS AND INTERMEDIATES FOR PREPARING JAK INHIBITORS | SUN PHARMACEUTICAL INDUSTRIES, INC. | 2023-09-14 | — | — | US | disclosed |
| CN-115989226-A | Processes and intermediates for preparing JAK inhibitors | 康塞特医药品有限公司 | 2023-04-18 | — | — | CN | disclosed |
| WO-2022006136-A1 | METHODS AND INTERMEDIATES FOR PREPARING JAK INHIBITORS | CONCERT PHARMACEUTICALS, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| CN-112566636-A | Compound and use thereof | 优曼尼蒂治疗公司 | 2021-03-26 | — | — | CN | disclosed |
| EP-3784234-A1 | COMPOUNDS AND USES THEREOF | Yumanity Therapeutics, Inc. (US) | 2021-03-03 | — | — | EP | disclosed |
| US-10919885-B2 | Compounds and uses thereof | YUMANITY THERAPEUTICS, INC. (US) | 2021-02-16 | — | — | US | disclosed |
| US-10919885-B2 | Compounds and uses thereof | YUMANITY THERAPEUTICS, INC. (US) | 2021-02-16 | — | — | US | disclosed |
| US-20190330198-A1 | COMPOUNDS AND USES THEREOF | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-31 | — | — | US | disclosed |
| US-7846956-B2 | Malononitrile compound as pesticides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-12-07 | — | — | US | disclosed |
| US-7846956-B2 | Malononitrile compound as pesticides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-12-07 | — | — | US | disclosed |
| US-20090149425-A1 | Malononitrile compound as pesticides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-06-11 | — | — | US | disclosed |
| US-20090149425-A1 | Malononitrile compound as pesticides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-06-11 | — | — | US | disclosed |
| US-20090149425-A1 | Malononitrile compound as pesticides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-06-11 | — | — | US | disclosed |
| EP-1704143-B1 | MALONONITRILE COMPOUND AS PESTICIDES | SUMITOMO CHEMICAL CO (JP) | 2008-09-03 | — | — | EP | disclosed |
| EP-1704143-B1 | MALONONITRILE COMPOUND AS PESTICIDES | SUMITOMO CHEMICAL CO (JP) | 2008-09-03 | — | — | EP | disclosed |
| CN-1910156-A | Malononitrile compound as pesticide | SUMITOMO CHEMICAL CO (JP) | 2007-02-07 | — | — | CN | disclosed |
| EP-1704143-A1 | MALONONITRILE COMPOUND AS PESTICIDES | Sumitomo Chemical Company, Limited (JP) | 2006-09-27 | — | — | EP | disclosed |
| WO-2005068432-A1 | MALONONITRILE COMPOUND AS PESTICIDES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2005-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10919885-B2 | Compounds and uses thereof | NLN, ACHE, CLN6 | KLKB1 2679/4885L3MBTL1 3366/4885MAPK8 4173/4885 |
| US-20190330198-A1 | COMPOUNDS AND USES THEREOF | NLN, ACHE, CLN6 | KLKB1 2679/4885L3MBTL1 3366/4885MAPK8 4173/4885 |
| US-20230286953-A1 | METHODS AND INTERMEDIATES FOR PREPARING JAK INHIBITORS | JAK2, JAK1, JAK3 | KLKB1 1521/4885L3MBTL1 3076/4885MAPK8 133/4885 |
| US-20090149425-A1 | Malononitrile compound as pesticides | NR0B1, RTN4, OR10J3 | KLKB1 3914/4885L3MBTL1 285/4885MAPK8 2198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.