Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.36 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.36 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.32 |
| ▸ | CPT1A | P50416 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30564937 | 0.84 | MAPT (0.40) | MAPTSMN1; SMN2GALR3BLMTSHR | |
| Methacrylic Acid SCHEMBL7979734 | 0.77 | MAPT (0.47) | MAPTSMN1; SMN2GALR3BLMTSHR | |
| Methacrylic Acid SCHEMBL27695566 | 0.76 | SLC7A5 (0.33) | TSHRTGFBR1 | |
| Methacrylic Acid SCHEMBL27466382 | 0.75 | MAPT (0.43) | MAPTSMN1; SMN2GALR3BLMTSHR | |
| Methacrylic Acid SCHEMBL26931734 | 0.74 | TDP1 (0.35) | TSHRALDH1A1TGFBR1 | |
| Methacrylic Acid SCHEMBL25248517 | 0.73 | MAPT (0.42) | MAPTSMN1; SMN2GALR3BLMTSHR | |
| Methacrylic Acid SCHEMBL29242006 | 0.73 | TP53 (0.32) | TGFBR1 | |
| Methacrylic Acid SCHEMBL9636345 | 0.72 | TSHR (0.33) | BLMTSHRLMNAALDH1A1APEX1 | |
| Methacrylic Acid SCHEMBL17744912 | 0.70 | TGFBR1 (0.32) | TSHRTGFBR1 | |
| Methacrylic Acid SCHEMBL10794068 | 0.70 | SLC7A5 (0.39) | MAPTSMN1; SMN2GALR3BLMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116574424-A | Emulsion special for water-based asphalt-based waterproof paint and preparation method and application thereof | 广东衡光新材料科技有限公司 | 2023-08-11 | — | — | CN | disclosed |