Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.51 |
| ▸ | CTSB | P07858 | 4/20 | 0.51 |
| ▸ | CTSC | P53634 | 2/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | USP5 | P45974 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290432 | 0.93 | CTSL (0.46) | CTSLCTSBCTSSSMN1; SMN2MEN1 | |
| SCHEMBL290579 | 0.93 | CTSL (0.47) | CTSLCTSBCTSCCTSSSMN1; SMN2 | |
| SCHEMBL289590 | 0.85 | CTSC (0.38) | CTSLCTSBCTSCCTSS | |
| SCHEMBL2890331 | 0.84 | CTSC (0.51) | CTSLCTSBCTSCCTSSSMN1; SMN2 | |
| SCHEMBL12493856 | 0.84 | SMN1; SMN2 (0.52) | CTSLCTSBCTSCSMN1; SMN2TSHR | |
| SCHEMBL290024 | 0.81 | CTSC (0.49) | CTSLCTSBCTSCCTSS | |
| SCHEMBL288986 | 0.81 | MMP1 (0.41) | CTSLCTSBCTSCCTSS | |
| SCHEMBL12494254 | 0.80 | CTSL (0.53) | CTSLCTSBCTSCCTSSSMN1; SMN2 | |
| SCHEMBL290110 | 0.80 | CTSC (0.56) | CTSLCTSBCTSCCTSS | |
| SCHEMBL290246 | 0.80 | ALDH1A1 (0.41) | CTSLCTSBCTSCCTSSCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427445-A1 | SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 | AstraZeneca AB (SE) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128324-A1 | SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 | ASTRAZENECA AB (SE) | 2010-11-11 | — | — | WO | disclosed |