Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 8/20 | 0.49 |
| ▸ | JAK1 | P23458 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | BUB1B | O60566 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | BRD2 | P25440 | 1/20 | 0.47 |
| ▸ | WEE1 | P30291 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | BCL6 | P41182 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29052245 | 0.91 | PTK2 (0.54) | NTRK1JAK3NTRK3NTRK2JAK2 | |
| SCHEMBL30468492 | 0.83 | BRD4 (0.53) | BRD4NTRK1JAK1HDAC1WEE1 | |
| Hydrochloric Acid SCHEMBL29052418 | 0.83 | BRD4 (0.52) | BRD4NTRK1JAK1HDAC1WEE1 | |
| SCHEMBL29051926 | 0.80 | BTK (0.47) | NTRK1JAK3FLT3ALK | |
| SCHEMBL29051738 | 0.78 | PTK2 (0.50) | FLT3ALK | |
| SCHEMBL29052266 | 0.78 | INSR (0.46) | NTRK1FLT3ALK | |
| SCHEMBL29051826 | 0.74 | CHEK1 (0.45) | NTRK1FLT3ALK | |
| SCHEMBL30468456 | 0.73 | NTRK1 (0.47) | BRD4NTRK1JAK1HDAC1BCL6 | |
| SCHEMBL29051917 | 0.73 | NTRK1 (0.47) | BRD4NTRK1JAK1HDAC1BCL6 | |
| SCHEMBL30306487 | 0.70 | BRD4 (1.00) | BRD4JAK1JAK3BUB1BJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332910-A | 2-aminopyrimidine derivatives as kinase inhibitors, preparation and use thereof | 江苏威凯尔医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |