Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 4/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.45 |
| ▸ | INSR | P06213 | 4/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.45 |
| ▸ | FLT3 | P36888 | 5/20 | 0.45 |
| ▸ | AXL | P30530 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29051826 | 0.90 | CHEK1 (0.45) | BTKMETNTRK1INSRALK | |
| SCHEMBL29052245 | 0.86 | PTK2 (0.54) | PTK2NTRK1JAK3 | |
| SCHEMBL29051738 | 0.83 | PTK2 (0.50) | BTKPTK2METINSRALK | |
| SCHEMBL29052266 | 0.82 | INSR (0.46) | BTKPTK2METNTRK1INSR | |
| SCHEMBL29051777 | 0.80 | BRD4 (0.54) | NTRK1ALKFLT3JAK3 | |
| SCHEMBL29051940 | 0.74 | FLT3 (0.46) | BTKPTK2METNTRK1INSR | |
| SCHEMBL29051729 | 0.73 | FLT3 (0.48) | BTKCHEK1FLT3JAK3 | |
| SCHEMBL29051865 | 0.73 | FLT3 (0.47) | BTKPTK2METNTRK1INSR | |
| SCHEMBL30468444 | 0.70 | CCR4 (0.38) | BTKPTK2NTRK1ALKFLT3 | |
| SCHEMBL29051929 | 0.70 | CCR4 (0.38) | BTKPTK2NTRK1ALKFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332910-A | 2-aminopyrimidine derivatives as kinase inhibitors, preparation and use thereof | 江苏威凯尔医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |