Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.45 |
| ▸ | FLT3 | P36888 | 9/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CCNK | O75909 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CCND3 | P30281 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 3/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29051926 | 0.90 | BTK (0.47) | CHEK1FLT3METBTKINSR | |
| SCHEMBL30498941 | 0.78 | AXL (0.71) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL25838992 | 0.78 | AXL (0.71) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL29052245 | 0.77 | PTK2 (0.54) | NTRK1 | |
| SCHEMBL29051777 | 0.74 | BRD4 (0.54) | FLT3NTRK1ALK | |
| SCHEMBL29051715 | 0.74 | ALK (0.44) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL29051738 | 0.73 | PTK2 (0.50) | CHEK1FLT3METBTKINSR | |
| SCHEMBL23754874 | 0.73 | CHEK1 (0.57) | CHEK1FLT3MAPTESR2 | |
| SCHEMBL30088400 | 0.73 | CHEK1 (0.57) | CHEK1FLT3MAPTESR2 | |
| SCHEMBL29052266 | 0.73 | INSR (0.46) | CHEK1FLT3METBTKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332910-A | 2-aminopyrimidine derivatives as kinase inhibitors, preparation and use thereof | 江苏威凯尔医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |