Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.45 |
| ▸ | FLT3 | P36888 | 8/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.43 |
| ▸ | INSR | P06213 | 3/20 | 0.43 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29051724 | 0.90 | FLT3 (0.46) | BTKFLT3CHEK1ALKINSR | |
| SCHEMBL29051729 | 0.82 | FLT3 (0.48) | BTKFLT3CHEK1JAK2JAK1 | |
| SCHEMBL29051884 | 0.82 | FLT3 (0.45) | FLT3CHEK1JAK2TYK2 | |
| SCHEMBL29052199 | 0.81 | FLT3 (0.49) | FLT3CHEK1AXLTYRO3MERTK | |
| SCHEMBL29052266 | 0.80 | INSR (0.46) | BTKFLT3CHEK1ALKINSR | |
| SCHEMBL29052136 | 0.79 | FLT3 (0.46) | BTKFLT3CHEK1JAK2 | |
| SCHEMBL29052409 | 0.79 | FLT3 (0.44) | FLT3CHEK1JAK2JAK1TYK2 | |
| SCHEMBL29051738 | 0.76 | PTK2 (0.50) | BTKFLT3CHEK1ALKINSR | |
| SCHEMBL29051940 | 0.75 | FLT3 (0.46) | BTKFLT3CHEK1ALKINSR | |
| SCHEMBL29051841 | 0.74 | CDK4 (0.45) | FLT3CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332910-A | 2-aminopyrimidine derivatives as kinase inhibitors, preparation and use thereof | 江苏威凯尔医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |