Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 16/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 11/20 | 0.44 |
| ▸ | JAK2 | O60674 | 5/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29051884 | 0.84 | FLT3 (0.45) | FLT3CHEK1JAK2TYK2ACVR1 | |
| SCHEMBL29051729 | 0.80 | FLT3 (0.48) | FLT3CHEK1JAK2JAK1TYK2 | |
| SCHEMBL29052199 | 0.79 | FLT3 (0.49) | FLT3CHEK1JAK2KITRPS6KB1 | |
| SCHEMBL29051907 | 0.79 | BTK (0.45) | FLT3CHEK1JAK2JAK1TYK2 | |
| SCHEMBL29052136 | 0.78 | FLT3 (0.46) | FLT3CHEK1JAK2KITRPS6KB1 | |
| Hydrochloric Acid SCHEMBL29051856 | 0.74 | WEE1 (0.44) | ACVR1 | |
| SCHEMBL29051940 | 0.73 | FLT3 (0.46) | FLT3CHEK1JAK2JAK1TYK2 | |
| SCHEMBL16634913 | 0.72 | KCNA1 (0.49) | — | |
| SCHEMBL29051865 | 0.72 | FLT3 (0.47) | FLT3CHEK1JAK2TYK2JAK3 | |
| SCHEMBL29052266 | 0.72 | INSR (0.46) | FLT3CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332910-A | 2-aminopyrimidine derivatives as kinase inhibitors, preparation and use thereof | 江苏威凯尔医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |