Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 14/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 10/20 | 0.45 |
| ▸ | JAK2 | O60674 | 4/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29051729 | 0.88 | FLT3 (0.48) | FLT3CHEK1JAK2TYK2 | |
| SCHEMBL29052199 | 0.87 | FLT3 (0.49) | FLT3CHEK1JAK2CSF1R | |
| SCHEMBL29052136 | 0.85 | FLT3 (0.46) | FLT3CHEK1JAK2PTK2PTK2B | |
| SCHEMBL29052409 | 0.84 | FLT3 (0.44) | FLT3CHEK1JAK2ACVR1CSF1R | |
| SCHEMBL29051907 | 0.82 | BTK (0.45) | FLT3CHEK1JAK2TYK2 | |
| SCHEMBL29051940 | 0.77 | FLT3 (0.46) | FLT3CHEK1JAK2TYK2PTK2 | |
| SCHEMBL29051865 | 0.76 | FLT3 (0.47) | FLT3CHEK1JAK2CSF1RTYK2 | |
| SCHEMBL29052266 | 0.76 | INSR (0.46) | FLT3CHEK1PTK2PTK2B | |
| SCHEMBL30468428 | 0.74 | ACVR1 (0.42) | ACVR1PTK2PTK2B | |
| SCHEMBL16634913 | 0.73 | KCNA1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332910-A | 2-aminopyrimidine derivatives as kinase inhibitors, preparation and use thereof | 江苏威凯尔医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |