Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL394368 | 0.91 | CNR2 (0.39) | SCN9AALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL2906906 | 0.88 | MAPT (0.45) | MAPTSCN9AALDH1A1KDM4ELMNA | |
| SCHEMBL1173457 | 0.86 | SCN9A (0.51) | SCN9AALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL13096065 | 0.84 | CYP3A4 (0.39) | SCN9ACYP3A4CYP2C19 | |
| SCHEMBL10293456 | 0.84 | ALDH1A1 (0.41) | SCN9AALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL391724 | 0.84 | ALDH1A1 (0.41) | SCN9AALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL4825604 | 0.83 | PRKCA (0.38) | MAPTSCN9AALDH1A1KDM4ELMNA | |
| SCHEMBL13096087 | 0.83 | MAPT (0.34) | MAPTSCN9AALDH1A1KDM4ELMNA | |
| SCHEMBL10082696 | 0.83 | SCN9A (0.37) | MAPTSCN9AALDH1A1CYP3A4CTSL | |
| SCHEMBL14277672 | 0.82 | ALDH1A1 (0.39) | SCN9AALDH1A1KDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9334282-B2 | Macrocyclic indoles as hepatitis C virus inhibitors | JANSSEN SCIENCES IRELAND UC (IE) | 2016-05-10 | — | — | US | disclosed |
| US-9334282-B2 | Macrocyclic indoles as hepatitis C virus inhibitors | JANSSEN SCIENCES IRELAND UC (IE) | 2016-05-10 | — | — | US | disclosed |
| US-20130267511-A1 | Macrocyclic Indoles as Hepatitis C Virus Inhibitors | JANSSEN SCIENCES IRELAND UC (IE) | 2013-10-10 | — | — | US | disclosed |
| US-20130267511-A1 | Macrocyclic Indoles as Hepatitis C Virus Inhibitors | JANSSEN SCIENCES IRELAND UC (IE) | 2013-10-10 | — | — | US | disclosed |
| US-8524716-B2 | Macrocyclic indoles as hepatitis C virus inhibitors | JANSSEN R&D IRELAND (IE) | 2013-09-03 | — | — | US | disclosed |
| US-8524716-B2 | Macrocyclic indoles as hepatitis C virus inhibitors | JANSSEN R&D IRELAND (IE) | 2013-09-03 | — | — | US | disclosed |
| EP-2238142-B1 | Macrocyclic indoles as hepatitis c virus inhibitors | JANSSEN R & D IRELAND (IE) | 2012-07-04 | — | — | EP | disclosed |
| US-20100273792-A1 | MACROCYCLIC INDOLES AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS LTD. | 2010-10-28 | — | — | US | disclosed |
| US-20100273792-A1 | MACROCYCLIC INDOLES AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS LTD. | 2010-10-28 | — | — | US | disclosed |
| US-7795250-B2 | Indole derivatives as antiviral agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2010-09-14 | — | — | US | disclosed |
| EP-1758857-B1 | INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | ANGELETTI P IST RICHERCHE BIO (IT) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009080836-A2 | MACROCYCLIC INDOLES AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2009-07-02 | — | — | WO | disclosed |
| US-20080261944-A1 | Indole Derivatives as Antiviral Agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2008-10-23 | — | — | US | disclosed |
| US-20070167447-A1 | Indole acetamides as inhibitors of the hepatitis c virus ns5b polymerase | ISTITUTO DI RICERCHE DI BIOLOGIA DI MOLECULOARE P. ANGELETTI SPA (IT) | 2007-07-19 | — | — | US | disclosed |
| EP-1758857-A1 | INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006029912-A1 | INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2006-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130267511-A1 | Macrocyclic Indoles as Hepatitis C Virus Inhibitors | IDO1, HCCS, IDO2 | MAPT 2712/4885SCN9A 3800/4885ALDH1A1 802/4885 |
| US-20080261944-A1 | Indole Derivatives as Antiviral Agents | IDO1, IDO2, IRF3 | MAPT 3543/4885SCN9A 4172/4885ALDH1A1 160/4885 |
| US-20070167447-A1 | Indole acetamides as inhibitors of the hepatitis c virus ns5b polymerase | IDO1, NAT1, AANAT | MAPT 4411/4885SCN9A 2221/4885ALDH1A1 119/4885 |
| US-20100273792-A1 | MACROCYCLIC INDOLES AS HEPATITIS C VIRUS INHIBITORS | IDO1, HCCS, IDO2 | MAPT 2712/4885SCN9A 3800/4885ALDH1A1 802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.