Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2905366 | 0.91 | MAPT (0.41) | CNR2SCN9ACYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL394814 | 0.89 | SCN9A (0.43) | CNR2SCN9ACYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL4825604 | 0.88 | PRKCA (0.38) | CNR2SCN9ACYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL1173457 | 0.88 | SCN9A (0.51) | SCN9ACYP3A4CYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL3095427 | 0.87 | PRKCA (0.38) | CNR2SCN9ACYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL393583 | 0.86 | PRKCA (0.39) | CNR2SCN9ACYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL923678 | 0.86 | PRKCA (0.36) | CNR2SCN9ACYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL391724 | 0.85 | ALDH1A1 (0.41) | CNR2SCN9ACYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL13096065 | 0.84 | CYP3A4 (0.39) | SCN9ACYP3A4CYP2C19 | |
| SCHEMBL14277672 | 0.84 | ALDH1A1 (0.39) | CNR2SCN9ACYP3A4CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103224506-A | Antiviral indoles | ANGELETTI P IST RICHERCHE BIO | 2013-07-31 | — | — | CN | disclosed |
| EP-2121707-B1 | ANTIVIRAL INDOLES | ANGELETTI P IST RICHERCHE BIO (IT) | 2012-12-05 | — | — | EP | disclosed |
| US-8101595-B2 | Antiviral indoles | Istituto di Ricerche di Biologia Molecolare P. Angletti SpA (IT) | 2012-01-24 | — | — | US | disclosed |
| US-7781422-B2 | Antiviral indoles | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2010-08-24 | — | — | US | disclosed |
| US-20100076046-A1 | Antiviral Indoles | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2010-03-25 | — | — | US | disclosed |
| EP-2121707-A1 | ANTIVIRAL INDOLES | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2009-11-25 | — | — | EP | disclosed |
| CN-101563352-A | Antiviral indoles | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-10-21 | — | — | CN | disclosed |
| WO-2008075103-A1 | ANTIVIRAL INDOLES | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2008-06-26 | — | — | WO | disclosed |
| US-20080153895-A1 | Antiviral indoles | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2008-06-26 | — | — | US | disclosed |
| US-20070167447-A1 | Indole acetamides as inhibitors of the hepatitis c virus ns5b polymerase | ISTITUTO DI RICERCHE DI BIOLOGIA DI MOLECULOARE P. ANGELETTI SPA (IT) | 2007-07-19 | — | — | US | disclosed |
| EP-1613634-A1 | INDOLE ACETAMIDES AS INHIBITORS OF THE HEPATITIS C VIRUS NS5B POLYMERASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004087714-A1 | INDOLE ACETAMIDES AS INHIBITORS OF THE HEPATITIS C VIRUS NS5B POLYMERASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076046-A1 | Antiviral Indoles | IDO1, ZC3HAV1, IFNAR1 | CNR2 873/4885SCN9A 4657/4885CYP3A4 720/4885 |
| US-20080153895-A1 | Antiviral indoles | IDO1, ZC3HAV1, YBX1 | CNR2 907/4885SCN9A 4630/4885CYP3A4 682/4885 |
| US-20070167447-A1 | Indole acetamides as inhibitors of the hepatitis c virus ns5b polymerase | IDO1, NAT1, AANAT | CNR2 303/4885SCN9A 2221/4885CYP3A4 116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.