Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.50 |
| ▸ | TYMS | P04818 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 4/20 | 0.37 |
| ▸ | DHFR | P00374 | 6/20 | 0.35 |
| ▸ | SLC19A1 | P41440 | 2/20 | 0.35 |
| ▸ | GART | P22102 | 2/20 | 0.35 |
| ▸ | ATIC | P31939 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15263068 | 0.90 | AKR1B1 (0.49) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL2906514 | 0.84 | TYMS (0.62) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL3980437 | 0.82 | AKR1B1 (0.47) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL27983477 | 0.79 | AKR1B1 (0.49) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL440460 | 0.78 | TYMS (0.70) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL2577686 | 0.78 | TYMS (0.70) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL15531651 | 0.77 | AKR1B1 (0.48) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL2509297 | 0.75 | NOS1 (0.46) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL9853745 | 0.72 | TYMS (0.71) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL10891557 | 0.72 | AKR1B1 (0.43) | AKR1B1TYMSKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2804609-B1 | TETRAHYDROFOLATES IN COMBINATION WITH EGFR-INHIBITORS | ISOFOL MEDICAL AB (SE) | 2018-06-13 | — | — | EP | disclosed |
| US-9675617-B2 | Tetrahydrofolates in combination with EGFR-inhibitors | ISOFOL MEDICAL AB (SE) | 2017-06-13 | — | — | US | disclosed |
| US-9585888-B2 | Reduction of toxicity of multi-targeting antifolates | ISOFOL MEDICAL AB (SE) | 2017-03-07 | — | — | US | disclosed |
| US-20150328218-A1 | Reduction Of Toxicity Of Multi-Targeting Antifolates | ISOFOL MEDICAL AB (SE) | 2015-11-19 | — | — | US | disclosed |
| US-9138435-B2 | Reduction of toxicity of multi-targeting antifolates | ISOFOL MEDICAL AB (SE) | 2015-09-22 | — | — | US | disclosed |
| EP-2804609-A1 | TETRAHYDROFOLATES IN COMBINATION WITH EGFR-INHIBITORS | Isofol Medical AB (SE) | 2014-11-26 | — | — | EP | disclosed |
| EP-2804608-A1 | ANTI-TUMOR ACTIVITY OF REDUCED FOLATES LIKE METHYLENE-TETRAHYDROFOLATE | Isofol Medical AB (SE) | 2014-11-26 | — | — | EP | disclosed |
| WO-2014143984-A1 | METHODS OF PRODUCING NUTRITIONAL SUPPLEMENTS USING MUSHROOMS FROM THE SPECIES PORIA COCOS OR FLAMMULINA VELUTIPES | JARROW FORMULAS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| US-20140271704-A1 | METHODS OF PRODUCING NUTRITIONAL SUPPLEMENTS USING MUSHROOMS FROM THE SPECIES Poria cocos OR Flammulina velutipes | JARROW FORMULAS, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| WO-2013107882-A1 | ANTI-TUMOR ACTIVITY OF REDUCED FOLATES LIKE METHYLENE-TETRAHYDROFOLATE | ISOFOL MEDICAL AB (SE) | 2013-07-25 | — | — | WO | disclosed |
| US-20100311762-A1 | Reduction of toxicity of multi-targeting antifolates | ISOFOL MEDICAL AB (SE) | 2010-12-09 | — | — | US | disclosed |
| EP-1699462-B1 | Combination of [6R]-methylenetetrahydrofolate with multi-targeting antifolates to reduce their toxicity while treating cancer | ISOFOL MEDICAL AB (SE) | 2010-08-11 | — | — | EP | disclosed |
| US-7682606-B2 | Methods of producing edible fungi containing activated folates and nutritional supplements containing activated folates | JARROW FORMULAS, INC. (US) | 2010-03-23 | — | — | US | disclosed |
| US-20080292596-A1 | METHODS OF PRODUCING EDIBLE FUNGI CONTAINING ACTIVATED FOLATES AND NUTRITIONAL SUPPLEMENTS CONTAINING ACTIVATED FOLATES | KKR LOAN ADMINISTRATION SERVICES LLC | 2008-11-27 | — | — | US | disclosed |
| US-7354590-B2 | Methods of producing edible fungi containing activated folates and nutritional supplements containing activated folates | JARROW FORMULAS, INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-20070249613-A1 | Reduction of Toxicity of Multi-Targeting Antifolates | BIOFOL AB (SE) | 2007-10-25 | — | — | US | disclosed |
| EP-1699462-A1 | REDUCTION OF TOXICITY OF MULTI-TARGETING ANTIFOLATES | Biofol AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005060973-A1 | REDUCTION OF TOXICITY OF MULTI-TARGETING ANTIFOLATES | BIOFOL AB (SE) | 2005-07-07 | — | — | WO | disclosed |
| US-20040258711-A1 | Methods of producing edible fungi containing activated folates and nutritional supplements containing activated folates | KKR LOAN ADMINISTRATION SERVICES LLC | 2004-12-23 | — | — | US | disclosed |
| WO-2004092334-A2 | METHODS OF PRODUCING EDIBLE FUNGI CONTAINING ACTIVATED FOLATES AND NUTRITIONAL SUPPLEMENTS CONTAINING ACTIVATED FOLATES | JARROW FORMULAS, INC. (US) | 2004-10-28 | — | — | WO | disclosed |