Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | DHFR | P00374 | 5/20 | 0.44 |
| ▸ | GART | P22102 | 4/20 | 0.44 |
| ▸ | ATIC | P31939 | 4/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15531651 | 0.89 | AKR1B1 (0.48) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL3980437 | 0.84 | AKR1B1 (0.47) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL2905540 | 0.84 | AKR1B1 (0.50) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL10891557 | 0.84 | AKR1B1 (0.43) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL15263068 | 0.83 | AKR1B1 (0.49) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL5665622 | 0.83 | TYMS (0.66) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL29619286 | 0.83 | TYMS (0.66) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL27812907 | 0.79 | TYMS (0.62) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL8897352 | 0.77 | TYMS (0.80) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL3195061 | 0.77 | MTHFD1 (0.44) | DHFRGARTATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023066865-A1 | PHARMACOLOGIC MODULATION OF 5-FLUOROURACIL BY FOLINIC ACID AND VITAMIN B6 FOR THE TREATMENT OF PATIENTS WITH CARCINOMA | MACHOVER DAVID (FR) | 2023-04-27 | — | — | WO | disclosed |
| CN-113286589-A | Methods and pharmaceutical compositions for treating cancer | 大卫·马舒瓦尔 | 2021-08-20 | — | — | CN | disclosed |
| EP-2804609-B1 | TETRAHYDROFOLATES IN COMBINATION WITH EGFR-INHIBITORS | ISOFOL MEDICAL AB (SE) | 2018-06-13 | — | — | EP | disclosed |
| US-9675617-B2 | Tetrahydrofolates in combination with EGFR-inhibitors | ISOFOL MEDICAL AB (SE) | 2017-06-13 | — | — | US | disclosed |
| US-9585888-B2 | Reduction of toxicity of multi-targeting antifolates | ISOFOL MEDICAL AB (SE) | 2017-03-07 | — | — | US | disclosed |
| US-20150328218-A1 | Reduction Of Toxicity Of Multi-Targeting Antifolates | ISOFOL MEDICAL AB (SE) | 2015-11-19 | — | — | US | disclosed |
| US-9138435-B2 | Reduction of toxicity of multi-targeting antifolates | ISOFOL MEDICAL AB (SE) | 2015-09-22 | — | — | US | disclosed |
| EP-2804609-A1 | TETRAHYDROFOLATES IN COMBINATION WITH EGFR-INHIBITORS | Isofol Medical AB (SE) | 2014-11-26 | — | — | EP | disclosed |
| EP-2804608-A1 | ANTI-TUMOR ACTIVITY OF REDUCED FOLATES LIKE METHYLENE-TETRAHYDROFOLATE | Isofol Medical AB (SE) | 2014-11-26 | — | — | EP | disclosed |
| WO-2013107882-A1 | ANTI-TUMOR ACTIVITY OF REDUCED FOLATES LIKE METHYLENE-TETRAHYDROFOLATE | ISOFOL MEDICAL AB (SE) | 2013-07-25 | — | — | WO | disclosed |
| EP-1059354-A2 | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby | Ceres Incorporated (US) | 2000-12-13 | — | — | EP | disclosed |
| US-6159506-A | Method for self-regulating stress-reduction using folic acid enriched dietary supplement compositions | NEUROGENESIS, INC. | 2000-12-12 | — | — | US | disclosed |
| US-6121195-A | STIMULATING CARBON FIXATION AND INCREASING THE GROWTH OF PLANTS BY ENHANCING THE AVAILABILITY OF C1-TETRAHYDROFOLATE IN THE LEAVES OF A PLANT | NONOMURA ARTHUR M (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0813510-A4 | METHODS AND COMPOSITIONS FOR ENHANCING FORMYLTETRAHYDROPTEROYLPOLYGLUTAMATE IN PLANTS | NONOMURA ARTHUR M (US) | 2000-07-26 | — | — | EP | disclosed |
| US-5922361-A | INCREASING LEVEL OF OPOIDS AND NEUROTRANSMITTER PRECURSORS TO ENABLE THE HUMAN BODY TO QUELL PERTURBATIONS TO ITS EQUILIBRIUM DUE TO STRESSFUL ASSUALTS | NEUROGENESIS, INC. | 1999-07-13 | — | — | US | disclosed |
| US-5846908-A | Methods and compositions for enhancing plant growth with p-amino- or p-nitro-benzoic acids | NONOMURA ARTHUR M (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0813510-A1 | METHODS AND COMPOSITIONS FOR ENHANCING FORMYLTETRAHYDROPTEROYLPOLYGLUTAMATE IN PLANTS | NONOMURA, Arthur M. (US) | 1997-12-29 | — | — | EP | disclosed |
| WO-1996027572-A1 | METHODS AND COMPOSITIONS FOR ENHANCING FORMYLTETRAHYDROPTEROYLPOLYGLUTAMATE IN PLANTS | NONOMURA ARTHUR M (US) | 1996-09-12 | — | — | WO | disclosed |
| US-5153309-A | PROCESS OF MAKING TETRAHYDROPTEROYLPOLY-L-GLUTAMIC ACID DERIVATIVES | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1992-10-06 | — | — | US | disclosed |
| WO-1992002241-A1 | A PROCESS OF MAKING TETRAHYDROPTEROYLPOLY-L-GLUTAMIC ACID DERIVATIVES | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, UNITED STATES DEPARTMENT OF COMMERCE (US) | 1992-02-20 | — | — | WO | disclosed |