Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 9/20 | 0.72 |
| ▸ | LPAR1 | Q92633 | 8/20 | 0.72 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.54 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.51 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.51 |
| ▸ | P2RY10 | O00398 | 2/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.49 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TSPO | P30536 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monoethanolamine SCHEMBL27549117 | 0.93 | LPAR3 (0.84) | LPAR3LPAR1LPAR2LPAR5 | |
| SCHEMBL23148274 | 0.93 | LPAR3 (0.84) | LPAR3LPAR1LPAR2LPAR5S1PR1 | |
| Monoethanolamine SCHEMBL27411197 | 0.93 | LPAR3 (0.84) | LPAR3LPAR1LPAR2LPAR5 | |
| Monoethanolamine SCHEMBL27885916 | 0.92 | LPAR1 (0.59) | LPAR3LPAR1LPAR2LPAR5S1PR1 | |
| Monoethanolamine SCHEMBL27635540 | 0.92 | LPAR3 (0.81) | LPAR3LPAR1LPAR2LPAR5 | |
| SCHEMBL11325872 | 0.89 | LPAR3 (0.78) | LPAR3LPAR1LPAR2LPAR5S1PR1 | |
| SCHEMBL11325869 | 0.89 | LPAR3 (0.78) | LPAR3LPAR1LPAR2LPAR5S1PR1 | |
| SCHEMBL31281823 | 0.88 | LPAR3 (0.75) | LPAR3LPAR1LPAR2LPAR5S1PR1 | |
| SCHEMBL446878 | 0.86 | PLA2G2C (0.65) | LPAR3LPAR1LPAR2P2RY10 | |
| SCHEMBL22556278 | 0.86 | PLA2G2C (0.65) | LPAR3LPAR1LPAR2P2RY10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116997342-A | Preventive or therapeutic agent for benign adult familial myoclonus epilepsy | 国立研究开发法人理化学研究所 | 2023-11-03 | — | — | CN | disclosed |
| CN-116438298-A | Large-scale synthesis of messenger RNA | 翻译生物公司 | 2023-07-14 | — | — | CN | disclosed |