Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 13/20 | 0.74 |
| ▸ | EGFR | P00533 | 9/20 | 0.63 |
| ▸ | MET | P08581 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | ROS1 | P08922 | 1/20 | 0.56 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29059835 | 0.92 | ALK (0.76) | ALKEGFRMETAURKAINSR | |
| SCHEMBL25308115 | 0.91 | ALK (0.71) | ALKEGFRMETINSR | |
| SCHEMBL25872148 | 0.91 | ALK (0.73) | ALKEGFRMETAURKAINSR | |
| SCHEMBL25299463 | 0.90 | ALK (0.72) | ALKEGFRMET | |
| SCHEMBL29059811 | 0.87 | ALK (0.65) | ALKEGFRMETAURKAINSR | |
| SCHEMBL29045219 | 0.86 | ALK (0.75) | ALKEGFRMETAURKAINSR | |
| SCHEMBL17411098 | 0.85 | ALK (1.00) | ALKEGFRMETAURKAINSR | |
| SCHEMBL29059813 | 0.84 | ALK (0.65) | ALKEGFRMETAURKAINSR | |
| SCHEMBL25869800 | 0.82 | ALK (0.75) | ALKEGFRMETAURKAINSR | |
| SCHEMBL21432251 | 0.82 | EGFR (0.79) | ALKEGFRMETINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116490184-A | Compounds for inhibiting EGFR mutant cancers and pharmaceutical uses thereof | J2H生物科技有限公司 | 2023-07-25 | — | — | CN | disclosed |